Enhancement of hepatitis B virus replication by its X protein in transgenic mice

被引：102

作者：

Xu, ZM

Yen, TSB

Wu, LY

Madden, CR

Tan, WJ

Slagle, BL

Ou, JH

机构：

[1] Univ So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA

[2] Univ So Calif, Dept Mol Biol & Biochem, Los Angeles, CA 90033 USA

[3] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94121 USA

[4] Vet Affairs Med Ctr, Pathol Serv, San Francisco, CA 94121 USA

[5] Baylor Coll Med, Dept Mol Virol & Microbiol, Houston, TX 77030 USA

来源：

JOURNAL OF VIROLOGY | 2002年 / 76卷 / 05期

关键词：

D O I：

10.1128/JVI.76.5.2579-2584.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Hepatitis B virus (HBV) X gene encodes a multifunctional protein that can regulate cellular signaling pathways, interact with cellular transcription factors, and induce hepatocellular oncogenesis. In spite of its diverse activities, the precise role of the X protein in the viral life cycle of HBV remains unclear. To investigate this question, we have produced transgenic mice that carry either the wild-type HBV genome or a mutated HBV genome incapable of expressing the 16.5-kDa X protein. Our results indicate that while the X protein is not absolutely essential for HBV replication or its maturation in transgenic mice, it can enhance viral replication, apparently by activating viral gene expression. These results demonstrate a transactivation role of the X protein in HBV replication in transgenic mice.

引用

收藏

页码：2579 / 2584

页数：6

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