Mitochondrial DNA repair pathways

被引：169

作者：

Croteau, DL

Stierum, RH

Bohr, VA

机构：

[1] NIA, Mol Genet Lab, NIH, Baltimore, MD 21224 USA

[2] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

来源：

MUTATION RESEARCH-DNA REPAIR | 1999年 / 434卷 / 03期

关键词：

mitochondrial DNA repair pathways; base excision repair; nucleotide excision repair;

D O I：

10.1016/S0921-8777(99)00025-7

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

DNA repair mechanisms are fairly well characterized for nuclear DNA while knowledge regarding the repair mechanisms operable in mitochondria is limited. Several lines of evidence suggest that mitochondria contain DNA repair mechanisms. DNA lesions are removed from mtDNA in cells exposed to various chemicals. Protein activities that process damaged DNA have been detected in mitochondria. As will be discussed, there is evidence for base excision repair (BER), direct damage reversal, mismatch repair, and recombinational repair mechanisms in mitochondria, while nucleotide excision repair (NER), as we know it from nuclear repair, is not present. (C) 1999 Elsevier Science B.V. All rights reserved.

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页码：137 / 148

页数：12

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