Optically active 2H-azepines: Synthesis and rearrangement into their 3H-isomers

被引：22

作者：

Hamprecht, D ^{[1
]}

Josten, J ^{[1
]}

Steglich, W ^{[1
]}

机构：

[1] CHRISTIAN ALBRECHTS UNIV KIEL,INST ORGAN CHEM,D-80333 MUNICH,GERMANY

来源：

TETRAHEDRON | 1996年 / 52卷 / 33期

关键词：

D O I：

10.1016/0040-4020(96)00629-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general synthesis of optically active 2H-azepiaes 12 starting from a-amino acids is described. The 2H-azepines easily rearrange into the corresponding 3H-isomers 18. The pungent taste of chalciporone (1) and simple 2,7-dialkylsubstituted 2H-azepines is due to the 2H-azepine nucleus and is independent of the absolute configuration at C-2. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：10883 / 10902

页数：20

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