Playing with bone and fat

被引：429

作者：

Gimble, JM

Zvonic, S

Floyd, ZE

Kassem, M

Nuttall, ME

机构：

[1] Louisiana State Univ Syst, Stem Cell Lab, Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA

[2] Odense Univ Hosp, Dept Endocrinol, Odense, Denmark

[3] Centocor Inc, Johnson & Johnson, Philadelphia, PA USA

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2006年 / 98卷 / 02期

关键词：

adipoctye; bone; fat; mesenchymal stern cell; osteoblast;

D O I：

10.1002/jcb.20777

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The relationship between bone and fat formation within the bone marrow microenvironment is complex and remains an area of active investigation. Classical in vitro and in vivo studies strongly support an inverse relationship between the commitment of bone marrow-derived mesenchymal stem cells or stromal cells to the adipoctye and osteoblast lineage pathways. In this review, we focus on the recent literature exploring the mechanisms underlying these differentiation events and discuss their implications relevant to osteoporosis and regenerative medicine.

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收藏

页码：251 / 266

页数：16

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