The potential role of thrombopoietin in idiopathic thrombocytopenic purpura

被引：40

作者：

von dem Borne, A ^{[1
]}

Folman, C ^{[1
]}

van den Oudenrijn, S ^{[1
]}

Linthorst, G ^{[1
]}

de Jong, S ^{[1
]}

de Haas, M ^{[1
]}

机构：

[1] Univ Amsterdam, Dept Med, Acad Med Ctr, NL-1105 AZ Amsterdam, Netherlands

来源：

BLOOD REVIEWS | 2002年 / 16卷 / 01期

关键词：

D O I：

10.1054/blre.2001.0184

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Thrombopoietin (TPO) plays a central role in the pathogenesis of idiopathic thrombocytopenic purpura (ITP), as it does in other immune-mediated thrombocytopenias. Because TPO is bound and internalized by platelets, it is destroyed together with platelets at an accelerated rate in the macrophage system. Because the spleen acts as a TPO sink, compensation of the decreased platelet count by an increased production in the bone marrow is insufficient. This aspect of ITP, as well as the use of TPO in the treatment of ITP, will be the focus of this article. (C) 2002, Elsevier Science Ltd. All rights reserved.

引用

页码：57 / 59

页数：3

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