Endothelial progenitor cells for vascular regeneration

被引：110

作者：

Asahara, T ^{[1
]}

Isner, JM ^{[1
]}

机构：

[1] Tufts Univ, St Elizabeths Med Ctr, Sch Med, Boston, MA 02135 USA

来源：

JOURNAL OF HEMATOTHERAPY & STEM CELL RESEARCH | 2002年 / 11卷 / 02期

关键词：

D O I：

10.1089/152581602753658385

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The basis for native as well as therapeutic neovascularization is not restricted to angiogenesis but includes postnatal vasculogenesis. Our laboratory and others' have established that bone marrow-derived endothelial progenitor cells (EPCs) are present in the systemic circulation, are augmented in response to certain cytokines and/or tissue ischemia, and home to as well as incorporate into sites of neovascularization. Given the background, EPCs have been investigated as therapeutic agents in these studies of supply-side angiogenesis under pathological as well as physiological conditions. This review discusses the therapeutic potential of EPCs for cardiovascular ischemic diseases.

引用

页码：171 / 178

页数：8

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