共 102 条
Coordinate transcriptional regulation of transport and metabolism
被引:53
作者:

Eloranta, JJ
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机构:
Univ Zurich Hosp, Div Gastroenterol & Hepatol, CH-8091 Zurich, Switzerland Univ Zurich Hosp, Div Gastroenterol & Hepatol, CH-8091 Zurich, Switzerland

Meier, PJ
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机构: Univ Zurich Hosp, Div Gastroenterol & Hepatol, CH-8091 Zurich, Switzerland

Kullak-Ublick, GA
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机构: Univ Zurich Hosp, Div Gastroenterol & Hepatol, CH-8091 Zurich, Switzerland
机构:
[1] Univ Zurich Hosp, Div Gastroenterol & Hepatol, CH-8091 Zurich, Switzerland
[2] Univ Zurich Hosp, Dept Internal Med, Div Clin Pharmacol & Toxicol, CH-8091 Zurich, Switzerland
来源:
PHASE II CONJUGATION ENZYMES AND TRANSPORT SYSTEMS
|
2005年
/
400卷
关键词:
D O I:
10.1016/S0076-6879(05)00028-5
中图分类号:
Q5 [生物化学];
学科分类号:
071010 ;
081704 ;
摘要:
Intestinal absorption and hepatic clearance of drugs, xenobiotics, and bile acids are mediated by transporter proteins expressed at the plasma membranes of intestinal epithelial cells and liver parenchymal cells in a polarized manner. Within enterocytes and hepatocytes, these exogenous or endogenous, potentially toxic compounds may be metabolized by phase I cytochrome P450 (CYP) and phase 11 conjugating enzymes. Many transporter proteins and metabolizing enzymes are subject to direct translational modification, enabling very rapid changes in their activity. However, to achieve intermediate and longer term changes in transport and enzyme activities, the genes encoding drug and bile acid transporters, as well as the CYP and conjugating enzymes, are regulated by a complex network of transcriptional cascades. These are typically mediated by specific members of the nuclear receptor family of transcription factors, particularly FXR, SHP, PXR, CAR, and HNF-4 alpha. Most nuclear receptors are activated by specific ligands, including numerous xenobiotics (PXR, CAR) and bile acids (FXR). The fine-tuning of transcriptional control of drug and bile acid homeostasis depends on regulated interactions of specific nuclear receptors with their target genes.
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页码:511 / +
页数:21
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共 102 条
[1]
Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor
[J].
Ananthanarayanan, M
;
Balasubramanian, N
;
Makishima, M
;
Mangelsdorf, DJ
;
Suchy, FJ
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
2001, 276 (31)
:28857-28865

Ananthanarayanan, M
论文数: 0 引用数: 0
h-index: 0
机构: Mt Sinai Med Ctr, Dept Pediat, Lab Dev & Mol Hepatol, New York, NY 10029 USA

Balasubramanian, N
论文数: 0 引用数: 0
h-index: 0
机构: Mt Sinai Med Ctr, Dept Pediat, Lab Dev & Mol Hepatol, New York, NY 10029 USA

Makishima, M
论文数: 0 引用数: 0
h-index: 0
机构: Mt Sinai Med Ctr, Dept Pediat, Lab Dev & Mol Hepatol, New York, NY 10029 USA

Mangelsdorf, DJ
论文数: 0 引用数: 0
h-index: 0
机构: Mt Sinai Med Ctr, Dept Pediat, Lab Dev & Mol Hepatol, New York, NY 10029 USA

Suchy, FJ
论文数: 0 引用数: 0
h-index: 0
机构: Mt Sinai Med Ctr, Dept Pediat, Lab Dev & Mol Hepatol, New York, NY 10029 USA
[2]
Neither intestinal sequestration of bile acids nor common bile duct ligation modulate the expression and function of the rat ileal bile acid transporter
[J].
Arrese, M
;
Trauner, M
;
Sacchiero, RJ
;
Crossman, MW
;
Shneider, BL
.
HEPATOLOGY,
1998, 28 (04)
:1081-1087

Arrese, M
论文数: 0 引用数: 0
h-index: 0
机构: CUNY Mt Sinai Sch Med, Dept Pediat, New York, NY 10029 USA

Trauner, M
论文数: 0 引用数: 0
h-index: 0
机构: CUNY Mt Sinai Sch Med, Dept Pediat, New York, NY 10029 USA

Sacchiero, RJ
论文数: 0 引用数: 0
h-index: 0
机构: CUNY Mt Sinai Sch Med, Dept Pediat, New York, NY 10029 USA

Crossman, MW
论文数: 0 引用数: 0
h-index: 0
机构: CUNY Mt Sinai Sch Med, Dept Pediat, New York, NY 10029 USA

Shneider, BL
论文数: 0 引用数: 0
h-index: 0
机构: CUNY Mt Sinai Sch Med, Dept Pediat, New York, NY 10029 USA
[3]
Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice
[J].
Assem, M
;
Schuetz, EG
;
Leggas, M
;
Sun, DX
;
Yasuda, K
;
Reid, G
;
Zelcer, N
;
Adachi, M
;
Strom, S
;
Evans, RM
;
Moore, DD
;
Borst, P
;
Schuetz, JD
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
2004, 279 (21)
:22250-22257

Assem, M
论文数: 0 引用数: 0
h-index: 0
机构: St Jude Childrens Res Hosp, Dept Pharmaceut Sci, Memphis, TN 38105 USA

Schuetz, EG
论文数: 0 引用数: 0
h-index: 0
机构: St Jude Childrens Res Hosp, Dept Pharmaceut Sci, Memphis, TN 38105 USA

Leggas, M
论文数: 0 引用数: 0
h-index: 0
机构: St Jude Childrens Res Hosp, Dept Pharmaceut Sci, Memphis, TN 38105 USA

Sun, DX
论文数: 0 引用数: 0
h-index: 0
机构: St Jude Childrens Res Hosp, Dept Pharmaceut Sci, Memphis, TN 38105 USA

Yasuda, K
论文数: 0 引用数: 0
h-index: 0
机构: St Jude Childrens Res Hosp, Dept Pharmaceut Sci, Memphis, TN 38105 USA

Reid, G
论文数: 0 引用数: 0
h-index: 0
机构: St Jude Childrens Res Hosp, Dept Pharmaceut Sci, Memphis, TN 38105 USA

Zelcer, N
论文数: 0 引用数: 0
h-index: 0
机构: St Jude Childrens Res Hosp, Dept Pharmaceut Sci, Memphis, TN 38105 USA

Adachi, M
论文数: 0 引用数: 0
h-index: 0
机构: St Jude Childrens Res Hosp, Dept Pharmaceut Sci, Memphis, TN 38105 USA

Strom, S
论文数: 0 引用数: 0
h-index: 0
机构: St Jude Childrens Res Hosp, Dept Pharmaceut Sci, Memphis, TN 38105 USA

Evans, RM
论文数: 0 引用数: 0
h-index: 0
机构: St Jude Childrens Res Hosp, Dept Pharmaceut Sci, Memphis, TN 38105 USA

Moore, DD
论文数: 0 引用数: 0
h-index: 0
机构: St Jude Childrens Res Hosp, Dept Pharmaceut Sci, Memphis, TN 38105 USA

Borst, P
论文数: 0 引用数: 0
h-index: 0
机构: St Jude Childrens Res Hosp, Dept Pharmaceut Sci, Memphis, TN 38105 USA

Schuetz, JD
论文数: 0 引用数: 0
h-index: 0
机构: St Jude Childrens Res Hosp, Dept Pharmaceut Sci, Memphis, TN 38105 USA
[4]
Repression of CAR-mediated transactivation of CYP2B genes by the orphan nuclear receptor, short heterodimer partner (SHP)
[J].
Bae, YJ
;
Kemper, JK
;
Kemper, B
.
DNA AND CELL BIOLOGY,
2004, 23 (02)
:81-91

Bae, YJ
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Illinois, Coll Med, Dept Mol & Integrat Physiol, Urbana, IL 61801 USA Univ Illinois, Coll Med, Dept Mol & Integrat Physiol, Urbana, IL 61801 USA

Kemper, JK
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Illinois, Coll Med, Dept Mol & Integrat Physiol, Urbana, IL 61801 USA Univ Illinois, Coll Med, Dept Mol & Integrat Physiol, Urbana, IL 61801 USA

Kemper, B
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Illinois, Coll Med, Dept Mol & Integrat Physiol, Urbana, IL 61801 USA Univ Illinois, Coll Med, Dept Mol & Integrat Physiol, Urbana, IL 61801 USA
[5]
FXR induces the UGT2B4 enzyme in hepatocytes: A potential mechanism of negative feedback control of FXR activity
[J].
Barbier, O
;
Torra, IP
;
Sirvent, A
;
Claudel, T
;
Blanquart, C
;
Duran-Sandoval, D
;
Kuipers, F
;
Kosykh, V
;
Fruchart, JC
;
Staels, B
.
GASTROENTEROLOGY,
2003, 124 (07)
:1926-1940

Barbier, O
论文数: 0 引用数: 0
h-index: 0
机构: Inst Pasteur, INSERM U545, Dept Atherosclerosis, F-59019 Lille, France

Torra, IP
论文数: 0 引用数: 0
h-index: 0
机构: Inst Pasteur, INSERM U545, Dept Atherosclerosis, F-59019 Lille, France

Sirvent, A
论文数: 0 引用数: 0
h-index: 0
机构: Inst Pasteur, INSERM U545, Dept Atherosclerosis, F-59019 Lille, France

Claudel, T
论文数: 0 引用数: 0
h-index: 0
机构: Inst Pasteur, INSERM U545, Dept Atherosclerosis, F-59019 Lille, France

Blanquart, C
论文数: 0 引用数: 0
h-index: 0
机构: Inst Pasteur, INSERM U545, Dept Atherosclerosis, F-59019 Lille, France

Duran-Sandoval, D
论文数: 0 引用数: 0
h-index: 0
机构: Inst Pasteur, INSERM U545, Dept Atherosclerosis, F-59019 Lille, France

Kuipers, F
论文数: 0 引用数: 0
h-index: 0
机构: Inst Pasteur, INSERM U545, Dept Atherosclerosis, F-59019 Lille, France

Kosykh, V
论文数: 0 引用数: 0
h-index: 0
机构: Inst Pasteur, INSERM U545, Dept Atherosclerosis, F-59019 Lille, France

Fruchart, JC
论文数: 0 引用数: 0
h-index: 0
机构: Inst Pasteur, INSERM U545, Dept Atherosclerosis, F-59019 Lille, France

Staels, B
论文数: 0 引用数: 0
h-index: 0
机构: Inst Pasteur, INSERM U545, Dept Atherosclerosis, F-59019 Lille, France
[6]
Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction
[J].
Bertilsson, G
;
Heidrich, J
;
Svensson, K
;
Åsman, M
;
Jendeberg, L
;
Sydow-Bäckman, M
;
Ohlsson, R
;
Postlind, H
;
Blomquist, P
;
Berkenstam, A
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1998, 95 (21)
:12208-12213

Bertilsson, G
论文数: 0 引用数: 0
h-index: 0
机构: Pharmacia & Upjohn Inc, Dept Mol Biol & Genomics, S-11287 Stockholm, Sweden

Heidrich, J
论文数: 0 引用数: 0
h-index: 0
机构: Pharmacia & Upjohn Inc, Dept Mol Biol & Genomics, S-11287 Stockholm, Sweden

Svensson, K
论文数: 0 引用数: 0
h-index: 0
机构: Pharmacia & Upjohn Inc, Dept Mol Biol & Genomics, S-11287 Stockholm, Sweden

Åsman, M
论文数: 0 引用数: 0
h-index: 0
机构: Pharmacia & Upjohn Inc, Dept Mol Biol & Genomics, S-11287 Stockholm, Sweden

Jendeberg, L
论文数: 0 引用数: 0
h-index: 0
机构: Pharmacia & Upjohn Inc, Dept Mol Biol & Genomics, S-11287 Stockholm, Sweden

Sydow-Bäckman, M
论文数: 0 引用数: 0
h-index: 0
机构: Pharmacia & Upjohn Inc, Dept Mol Biol & Genomics, S-11287 Stockholm, Sweden

Ohlsson, R
论文数: 0 引用数: 0
h-index: 0
机构: Pharmacia & Upjohn Inc, Dept Mol Biol & Genomics, S-11287 Stockholm, Sweden

Postlind, H
论文数: 0 引用数: 0
h-index: 0
机构: Pharmacia & Upjohn Inc, Dept Mol Biol & Genomics, S-11287 Stockholm, Sweden

Blomquist, P
论文数: 0 引用数: 0
h-index: 0
机构: Pharmacia & Upjohn Inc, Dept Mol Biol & Genomics, S-11287 Stockholm, Sweden

Berkenstam, A
论文数: 0 引用数: 0
h-index: 0
机构:
Pharmacia & Upjohn Inc, Dept Mol Biol & Genomics, S-11287 Stockholm, Sweden Pharmacia & Upjohn Inc, Dept Mol Biol & Genomics, S-11287 Stockholm, Sweden
[7]
Ligand-activated pregnane X receptor interferes with HNF-4 signaling by targeting a common coactivator PGC-1α -: Functional implications in hepatic cholesterol and glucose metabolism
[J].
Bhalla, S
;
Ozalp, C
;
Fang, SS
;
Xiang, LJ
;
Kemper, K
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
2004, 279 (43)
:45139-45147

Bhalla, S
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Illinois, Dept Mol & Integrat Physiol, Urbana, IL 61801 USA Univ Illinois, Dept Mol & Integrat Physiol, Urbana, IL 61801 USA

Ozalp, C
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Illinois, Dept Mol & Integrat Physiol, Urbana, IL 61801 USA Univ Illinois, Dept Mol & Integrat Physiol, Urbana, IL 61801 USA

Fang, SS
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Illinois, Dept Mol & Integrat Physiol, Urbana, IL 61801 USA Univ Illinois, Dept Mol & Integrat Physiol, Urbana, IL 61801 USA

Xiang, LJ
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Illinois, Dept Mol & Integrat Physiol, Urbana, IL 61801 USA Univ Illinois, Dept Mol & Integrat Physiol, Urbana, IL 61801 USA

Kemper, K
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Illinois, Dept Mol & Integrat Physiol, Urbana, IL 61801 USA Univ Illinois, Dept Mol & Integrat Physiol, Urbana, IL 61801 USA
[8]
SXR, a novel steroid and xenobiotic-sensing nuclear receptor
[J].
Blumberg, B
;
Sabbagh, W
;
Juguilon, H
;
Bolado, J
;
van Meter, CM
;
Ono, ES
;
Evans, RM
.
GENES & DEVELOPMENT,
1998, 12 (20)
:3195-3205

Blumberg, B
论文数: 0 引用数: 0
h-index: 0
机构: Salk Inst Biol Studies, Gene Express Lab, La Jolla, CA 92037 USA

Sabbagh, W
论文数: 0 引用数: 0
h-index: 0
机构: Salk Inst Biol Studies, Gene Express Lab, La Jolla, CA 92037 USA

Juguilon, H
论文数: 0 引用数: 0
h-index: 0
机构: Salk Inst Biol Studies, Gene Express Lab, La Jolla, CA 92037 USA

Bolado, J
论文数: 0 引用数: 0
h-index: 0
机构: Salk Inst Biol Studies, Gene Express Lab, La Jolla, CA 92037 USA

van Meter, CM
论文数: 0 引用数: 0
h-index: 0
机构: Salk Inst Biol Studies, Gene Express Lab, La Jolla, CA 92037 USA

Ono, ES
论文数: 0 引用数: 0
h-index: 0
机构: Salk Inst Biol Studies, Gene Express Lab, La Jolla, CA 92037 USA

Evans, RM
论文数: 0 引用数: 0
h-index: 0
机构: Salk Inst Biol Studies, Gene Express Lab, La Jolla, CA 92037 USA
[9]
Orphan nuclear receptors - new ligands and new possibilities
[J].
Blumberg, B
;
Evans, RM
.
GENES & DEVELOPMENT,
1998, 12 (20)
:3149-3155

Blumberg, B
论文数: 0 引用数: 0
h-index: 0
机构: Salk Inst Biol Studies, Gene Express Lab, La Jolla, CA 92037 USA

Evans, RM
论文数: 0 引用数: 0
h-index: 0
机构: Salk Inst Biol Studies, Gene Express Lab, La Jolla, CA 92037 USA
[10]
Liver-enriched transcription factors and hepatocyte differentiation
[J].
Cereghini, S
.
FASEB JOURNAL,
1996, 10 (02)
:267-282

Cereghini, S
论文数: 0 引用数: 0
h-index: 0
机构: Unité 423-INSERM, Hôpital Necker Enfants Malades