Failure of trimethoprim/sulfamethoxazole prophylaxis for Pneumocystis carinii pneumonia with concurrent leucovorin use

被引：9

作者：

Razavi, B

Lund, B

Allen, BL

Schlesinger, L

机构：

[1] Indianapolis VAMC, Dept Internal Med, Indianapolis, IN 46202 USA

[2] Indiana Univ, Sch Med, Div Infect Dis, Indianapolis, IN 46202 USA

[3] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA

[4] Univ Iowa, Coll Pharm, Iowa City, IA 52242 USA

[5] VAMC, Dept Internal Med, Iowa City, IA USA

[6] Univ Iowa Hosp & Clin, Iowa City, IA 52242 USA

来源：

INFECTION | 2002年 / 30卷 / 01期

关键词：

treatment; antibiotic; prophylaxis; Pneumocystis carinii pneumonia (PCP); AIDS; trimethoprim/sulfamethoxazole (TMP/SMX) leucovorin;

D O I：

10.1007/s15010-001-1172-0

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Pneumocystis carinii is a common cause of pneumonia in patients with AIDS, however, the incidence has dropped with the availability of effective prophylactic regimens. First-Line treatment for both acute Pneumocystis pneumonia and chronic prophylaxis is trimethoprim/sulfamethoxazole (TMP/SMX). This combination can cause hypersensitivity reactions as well as myelosuppression. The simultaneous administration of leucovorin during acute treatment has been shown to reduce the incidence of neutropenia, but may interfere with the efficacy of TMP/SMX. We report a case of P. carinii pneumonia in a patient with AIDS who failed TMP/SMX prophylaxis while taking leucovorin.

引用

页码：41 / +

页数：3

共 7 条

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