Uric Acid Lowering to Prevent Kidney Function Loss in Diabetes: The Preventing Early Renal Function Loss (PERL) Allopurinol Study

被引：164

作者：

Maahs, David M. ^{[1
,2
]}

Caramori, Luiza ^{[3
,4
]}

Cherney, David Z. I. ^{[5
,6
]}

Galecki, Andrzej T. ^{[7
,8
]}

Gao, Chuanyun ^{[9
]}

Jalal, Diana ^{[2
]}

Perkins, Bruce A. ^{[5
,10
]}

Pop-Busui, Rodica ^{[11
]}

Rossing, Peter ^{[12
,13
,14
]}

Mauer, Michael ^{[3
,4
]}

Doria, Alessandro ^{[15
,16
]}

机构：

[1] Univ Colorado Denver, Barbara Davis Ctr Childhood Diabet, Aurora, CO USA

[2] Univ Colorado Denver, Div Renal Dis & Hypertens, Aurora, CO USA

[3] Univ Minnesota, Dept Pediat, Minneapolis, MN 55455 USA

[4] Univ Minnesota, Dept Med, Minneapolis, MN 55455 USA

[5] Univ Toronto, Dept Med, Toronto, ON, Canada

[6] Univ Toronto, Div Nephrol, Toronto, ON, Canada

[7] Univ Michigan, Sch Med, Inst Gerontol, Div Geriatr, Ann Arbor, MI USA

[8] Univ Michigan, Sch Publ Hlth, Dept Biostat, Ann Arbor, MI 48109 USA

[9] Joslin Diabet Ctr, Joslin Clin, Boston, MA 02215 USA

[10] Univ Toronto, Div Endocrinol, Toronto, ON, Canada

[11] Univ Michigan, Dept Internal Med, Div Metab Endocrinol & Diabet, Ann Arbor, MI 48109 USA

[12] Steno Diabet Ctr, DK-2820 Gentofte, Denmark

[13] Univ Aarhus, HEALTH, Aarhus, Denmark

[14] Univ Copenhagen, NNF CBMR, Copenhagen, Denmark

[15] Joslin Diabet Ctr, Sect Genet & Epidemiol, Boston, MA 02215 USA

[16] Harvard Univ, Sch Med, Dept Med, Boston, MA USA

来源：

CURRENT DIABETES REPORTS | 2013年 / 13卷 / 04期

关键词：

Uric acid; Kidney disease; Diabetes; Diabetic kidney disease; Glomerular filtration rate; Allopurinol; Diabetic nephropathy; Randomized clinical trial; Type; 1; diabetes; PERL trial; GLOMERULAR-FILTRATION-RATE; TOXIC EPIDERMAL NECROLYSIS; STEVENS-JOHNSON-SYNDROME; BLOOD-PRESSURE; ENDOTHELIAL DYSFUNCTION; METABOLIC SYNDROME; FUNCTION DECLINE; ESSENTIAL-HYPERTENSION; INDEPENDENT MECHANISM; CARDIOVASCULAR RISK;

D O I：

10.1007/s11892-013-0381-0

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Diabetic kidney disease causes significant morbidity and mortality among people with type 1 diabetes (T1D). Intensive glucose and blood pressure control have thus far failed to adequately curb this problem and therefore a major need for novel treatment approaches exists. Multiple observations link serum uric acid levels to kidney disease development and progression in diabetes and strongly argue that uric acid lowering should be tested as one such novel intervention. A pilot of such a trial, using allopurinol, is currently being conducted by the Preventing Early Renal Function Loss (PERL) Consortium. Although the PERL trial targets T1D individuals at highest risk of kidney function decline, the use of allopurinol as a renoprotective agent may also be relevant to a larger segment of the population with diabetes. As allopurinol is inexpensive and safe, it could be cost-effective even for relatively low-risk patients, pending the completion of appropriate trials at earlier stages.

引用

页码：550 / 559

页数：10

共 81 条

[1]

[Anonymous], JOSLINS DIABETES MEL

[2]

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