A newly identified single nucleotide polymorphism in the promoter of the matrix metalloproteinase-1 gene

被引：25

作者：

Jurajda, M ^{[1
]}

Muzík, J ^{[1
]}

Hollá, LI ^{[1
]}

Vácha, J ^{[1
]}

机构：

[1] Masaryk Univ, Dept Pathol Physiol, Fac Med, CS-66243 Brno, Czech Republic

来源：

MOLECULAR AND CELLULAR PROBES | 2002年 / 16卷 / 01期

关键词：

single nucleotide polymorphism; matrix metalloproteinase;

D O I：

10.1006/mcpr.2001.0398

中图分类号：

Q5 [生物化学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Matrix metalloproteinase-1 (MMP-1) is a member of the matrix metalloproteinase enzyme family that degrades components of the extracellular matrix. Recent studies have demonstrated several polymorphic sites in the promoter of the MMP-1 gene. A newly identified single nucleotide polymorphism (SNP) at position -519 in the promoter region of the MMP-1 gene is reported. This polymorphism consists in a guanine to adenine substitution. A linkage between polymorphisms -519A/G and -1607 1G/2G was also studied. (C) 2002 Elsevier Science Ltd.

引用

页码：63 / 66

页数：4

共 7 条

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[Anonymous], 1998, Primer 3

[2]

Kanamori Y, 1999, CANCER RES, V59, P4225

[3]

METALLOPROTEINASES AND THEIR INHIBITORS IN MATRIX REMODELING [J].