Differentiation of Diabetes by Pathophysiology, Natural History, and Prognosis

被引：479

作者：

Skyler, Jay S. ^{[1
]}

Bakris, George L. ^{[2
]}

Bonifacio, Ezio ^{[3
]}

Darsow, Tamara ^{[4
]}

Eckel, Robert H. ^{[5
]}

Groop, Leif ^{[6
]}

Groop, Per-Henrik ^{[7
,8
,9
,10
]}

Handelsman, Yehuda ^{[11
]}

Insel, Richard A. ^{[12
]}

Mathieu, Chantal ^{[13
]}

McElvaine, Allison T. ^{[4
]}

Palmer, Jerry P. ^{[14
,15
]}

Pugliese, Alberto ^{[1
]}

Schatz, Desmond A. ^{[16
]}

Sosenko, Jay M. ^{[17
]}

Wilding, John P. H. ^{[18
]}

Ratner, Robert E. ^{[4
]}

机构：

[1] Univ Miami, Miller Sch Med, Diabet Res Inst, Miami, FL 33136 USA

[2] Univ Chicago Med, Chicago, IL USA

[3] Tech Univ Dresden, Dresden, Germany

[4] Amer Diabet Assoc, Arlington, VA 22202 USA

[5] Univ Colorado, Anschutz Med Campus, Aurora, CO USA

[6] Lund Univ, Skane Univ Hosp, Malmo, Sweden

[7] Univ Helsinki, Abdominal Ctr Nephrol, Helsinki, Finland

[8] Helsinki Univ Hosp, Helsinki, Finland

[9] Folkhalsan Res Ctr, Folkhalsan Inst Genet, Helsinki, Finland

[10] Baker IDI Heart & Diabet Inst, Melbourne, Vic, Australia

[11] Metab Inst Amer, Tarzana, CA USA

[12] JDRF, New York, NY USA

[13] Katholieke Univ Leuven, Leuven, Belgium

[14] Univ Washington, Seattle, WA 98195 USA

[15] VA Puget Sound Hlth Care Syst, Seattle, WA USA

[16] Univ Florida, Coll Med, Gainesville, FL USA

[17] Univ Miami, Miller Sch Med, Miami, FL 33136 USA

[18] Aintree Univ Hosp NHS Fdn Trust, Liverpool, Merseyside, England

来源：

DIABETES | 2017年 / 66卷 / 02期

关键词：

BETA-CELL FUNCTION; IMPAIRED GLUCOSE-TOLERANCE; COTRANSPORTER; INHIBITOR; LIFE-STYLE INTERVENTION; ISLET AUTOIMMUNITY; C-PEPTIDE; CARDIOVASCULAR OUTCOMES; GLYCEMIC CONTROL; DOUBLE-BLIND; RISK SCORE;

D O I：

10.2337/db16-0806

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

The American Diabetes Association, JDRF, the European Association for the Study of Diabetes, and the American Association of Clinical Endocrinologists convened a research symposium, "The Differentiation of Diabetes by Pathophysiology, Natural History and Prognosis" on 10-12 October 2015. International experts in genetics, immunology, metabolism, endocrinology, and systems biology discussed genetic and environmental determinants of type 1 and type 2 diabetes risk and progression, as well as complications. The participants debated how to determine appropriate therapeutic approaches based on disease pathophysiology and stage and defined remaining research gaps hindering a personalized medical approach for diabetes to drive the field to address these gaps. The authors recommend a structure for data stratification to define the phenotypes and genotypes of subtypes of diabetes that will facilitate individualized treatment.

引用

页码：241 / 255

页数：15

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