Fat targets for insulin signaling

被引：20

作者：

Czech, MP ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Mol Sci Program, Worcester, MA 01605 USA

来源：

MOLECULAR CELL | 2002年 / 9卷 / 04期

关键词：

D O I：

10.1016/S1097-2765(02)00509-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Adipose cells control flux of fatty acids to peripheral tissues by storing and hydrolyzing triglyceride under hormonal control. New data reveal that insulin may regulate this process in part by promoting membrane trafficking of intracellular fatty acid transporters FATP1 and FATP4 to the plasma membrane.

引用

页码：695 / 696

页数：2

共 9 条

[1] Defective uptake and utilization of long chain fatty acids in muscle and adipose tissues of CD36 knockout mice [J].

Coburn, CT ;

Knapp, FF ;

Febbraio, M ;

Beets, AL ;

Silverstein, RL ;

Abumrad, NA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (42) :32523-32529

[2] Mechanism of insulin resistance in A-ZIP/F-1 fatless mice [J].

Kim, JK ;

Gavrilova, O ;

Chen, Y ;

Reitmann, ML ;

Shulman, GI .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (12) :8456-8460

[3] Insulin-regulated release from the endosomal recycling compartment is regulated by budding of specialized vesicles [J].

Lampson, MA ;

Schmoranzer, J ;

Zeigerer, A ;

Simon, SM ;

McGraw, TE .

MOLECULAR BIOLOGY OF THE CELL, 2001, 12 (11) :3489-3501

[4] Insulin induces the translocation of the fatty acid transporter FAT/CD36 to the plasma membrane [J].

Luiken, JJFP ;

Dyck, DJ ;

Han, XX ;

Tandon, NN ;

Arumugam, Y ;

Glatz, JFC ;

Bonen, A .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2002, 282 (02) :E491-E495

[5] Fatty acid transport: the roads taken [J].

Schaffer, JE .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2002, 282 (02) :E239-E246

[6] GLUT4 - At the cross roads between membrane trafficking and signal transduction [J].

Simpson, F ;

Whitehead, JP ;

James, DE .

TRAFFIC, 2001, 2 (01) :2-11

[7] Insulin causes fatty acid transport protein translocation and enhanced fatty acid uptake in adipocytes [J].

Stahl, A ;

Evans, JG ;

Pattel, S ;

Hirsch, D ;

Lodish, HF .

DEVELOPMENTAL CELL, 2002, 2 (04) :477-488

[8] Lipotoxic diseases [J].

Unger, RH .

ANNUAL REVIEW OF MEDICINE, 2002, 53 :319-336

[9] ADP-ribosylation factor 6 (ARF6) defines two insulin-regulated secretory pathways in adipocytes [J].

Yang, CZ ;

Mueckler, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (36) :25297-25300

← 1 →