Transcriptome and Proteome Analyses of Drug Interactions with Natural Products

被引：17

作者：

Fang, Hai ^{[1
,4
]}

Wang, Kankan ^{[2
]}

Zhang, Ji ^{[1
,2
,3
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Chinese Acad Sci, Shanghai Inst Biol Sci,Inst Hlth Sci,Key Lab Stem, Shanghai 200025, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Shanghai Inst Hematol, Shanghai 200025, Peoples R China

[3] Shanghai Jiao Tong Univ, Sch Med, Sino French Lab Genom & Life Sci, Ruijin Hosp, Shanghai 200025, Peoples R China

[4] Chinese Acad Sci, Grad Sch, Shanghai, Peoples R China

来源：

CURRENT DRUG METABOLISM | 2008年 / 9卷 / 10期

关键词：

Transcriptome; proteome; component plane presentation integrated self-organizing map; drug synergism; leukemia;

D O I：

10.2174/138920008786927802

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Advances in high-throughput technologies to measure genome-scale changes of genes, proteins, and other biomolecular components ('omics') in complex biological systems have dramatically revolutionized biomedical research. However, the benefits of utilizing omics information in drug development have not yet been fully realized. Fortunately, the integration of modern systems biology efforts with traditional medicine philosophies, together with integrative bioinformatics, has driven the development of a new drug discovery paradigm. Using leukemia as a disease model, therapeutic synergism between drugs and natural products has been investigated by incorporating transcriptomics and proteomics data into a network-like understanding. Here, these recent advancements will be discussed in detail, along with perspectives in the field of drug synergism.

引用

页码：1038 / 1048

页数：11

共 128 条

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