Clinical and attentional effects of acute nicotine treatment in Tourette's syndrome

被引:31
作者
Howson, AL
Batth, S
Ilivitsky, V
Boisjoli, A
Jaworski, M
Mahoney, C
Knott, VJ
机构
[1] Royal Ottawa Hosp, Dept Psychiat, Ottawa, ON K1A 7K4, Canada
[2] Vancouver Gen Hosp, Adult Metab Dis Clin, Vancouver Coastal Hlth Author, Vancouver, BC, Canada
[3] Ottawa Hosp, Tourette Syndrome Clin, Ottawa, ON, Canada
关键词
nicotine; Tourette's syndrome; tics; attention; performance; event-related potentials;
D O I
10.1016/j.eurpsy.2003.11.002
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Evidence from pre-clinical infrahuman investigations, open-label clinical trials, and a single controlled trial found acute nicotine treatment potentiated up to 4 weeks neuroleptic-induced reductions of dyskinetic symptoms characterizing Tourette's syndrome (TS). Given the attentional disturbances associated with this syndrome, and the improvements in attentional processes reported with nicotine, this randomized, double-blind, placebo-controlled trial examined the acute (4 h) and sustained (2 weeks) effects of a single dose of transdermal nicotine on clinical (i.e., tics), attentional (continuous performance task, event-related potentials, patient and parental reports) and behavioral symptoms in 23 children and adolescents with TS receiving neuroleptic treatment. In the 14 evaluable patients with complete primary efficacy data, nicotine (compared to placebo) failed to alter symptoms at 4 h but counteracted ERP-P300 signs of diminished attention seen 2 weeks following placebo treatment. Secondary efficacy measures, including patient self-reports and parental ratings, found nicotine to reduce complex tics and improve behaviors related to inattention. Additional work with intermittent dosing schedules is required to characterize optimal clinical and cognitive effects with nicotine treatment. (C) 2004 Published by Elsevier SAS.
引用
收藏
页码:102 / 112
页数:11
相关论文
共 55 条
[1]  
Achenbach T. M., 1991, Integrative guide for the 1991 CBCL/4-18, YSR, and the TRF profiles
[2]  
[Anonymous], NICOTINE CAFFEINE SO
[3]  
[Anonymous], 1992, NEUROPSY NEUROPSY BE
[4]  
Barkley R.A., 1990, Attention-deficit hyperactivity disorder: A handbook for diagnosis and treatment
[5]  
COHEN DJ, 1980, ARCH GEN PSYCHIAT, V37, P1350
[6]  
Cohen J., 1988, STAT POWER ANAL BEHA
[7]  
CONNERS CK, 1991, CONNERS RATING SCALE
[8]  
DEVOR EJ, 1993, J NEUROPSYCHIATRY CL, V5, P108
[9]  
DIMITSOPULOS T, 1993, J NEUROPSYCH CLIN N, V5, P108
[10]   AUDITORY EVOKED-POTENTIALS IN GILLES-DE-LA-TOURETTE SYNDROME [J].
DRAKE, ME ;
HIETTER, SA ;
PADAMADAN, H ;
BOGNER, JE ;
ANDREWS, JM ;
WEATE, S .
CLINICAL ELECTROENCEPHALOGRAPHY, 1992, 23 (01) :19-23