Cerebellum and psychiatric disorders

被引:129
作者
Baldacara, Leonardo [3 ,4 ,5 ]
Fiorani Borgio, Joao Guilherme [5 ]
Tavares de Lacerda, Acioly Luiz [1 ,2 ,5 ]
Jackowski, Andrea Parolin [5 ]
机构
[1] Ctr Pesquisa & Ensaios Clin Sinapse Bairral, Itapira, SP, Brazil
[2] Inst Sinapse Neurociencias Clin, Campinas, SP, Brazil
[3] Univ Fed Tocantins UFT, Palmas, SP, Brazil
[4] Irmandade Santa Casa Sao Paulo, Ctr Atencao Integrada Saude Mental CAISM, Sao Paulo, Brazil
[5] Univ Fed Sao Paulo, Dept Psiquiatria, Lab Interdisciplinar Neurociencias Clin, Sao Paulo, Brazil
关键词
cerebellum; schizophrenia; mood disorders; anxiety disorders; dementia;
D O I
10.1590/S1516-44462008000300016
中图分类号
R749 [精神病学];
学科分类号
100205 [精神病与精神卫生学];
摘要
Objective: The objective of this update article is to report structural and functional neuroimaging studies exploring the potential role of cerebellum in the pathophysiology of psychiatric disorders. Method: A non-systematic literature review was conducted by means of Medline using the following terms as a parameter: "cerebellum"; "cerebellar vermis", "schizophrenia", "bipolar disorder"; "depression", "anxiety disorders", "dementia" and "attention deficit hyperactivity disorder". The electronic search was done up to April 2008. Discussion: Structural and functional cerebellar abnormalities have been reported in many psychiatric disorders, namely schizophrenia, bipolar disorder, major depressive disorder, anxiety disorders, dementia and attention deficit hyperactivity disorder. Structural magnetic resonance imaging studies have reported smaller total cerebellar and vermal volumes in schizophrenia, mood disorders and attention deficit hyperactivity disorder Functional magnetic resonance imaging studies using cognitive paradigms have shown alterations in cerebellar activity in schizophrenia, anxiety disorders and attention deficit hyperactivity disorder In dementia, the cerebellum is affected in later stages of the disease. Conclusion: Contrasting with early theories, cerebellum appears to play a major role in different brain functions other than balance and motor control, including emotional regulation and cognition. Future studies are clearly needed to further elucidate the role of cerebellum in both normal and pathological behavior, mood regulation, and cognitive functioning.
引用
收藏
页码:281 / 289
页数:9
相关论文
共 81 条
[1]
Relationships between trait and state anxiety and the central benzodiazepine receptor:: a PET study [J].
Abadie, P ;
Boulenger, JP ;
Benali, K ;
Barré, L ;
Zarifian, E ;
Baron, JC .
EUROPEAN JOURNAL OF NEUROSCIENCE, 1999, 11 (04) :1470-1478
[2]
CEREBELLUM AND COGNITION - THE NEUROPSYCHOLOGICAL AND NEURORADIOLOGICAL EVIDENCE [J].
ACKERMANN, H ;
DAUM, I .
FORTSCHRITTE DER NEUROLOGIE PSYCHIATRIE, 1995, 63 (01) :30-37
[3]
T2-weighted image hyperintensities in major depression: focus on the basal ganglia [J].
Agid, R ;
Levin, T ;
Gomori, JM ;
Lerer, B ;
Bonne, O .
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2003, 6 (03) :215-224
[4]
Schizophrenia and cognitive dysmetria: A positron-emission tomography study of dysfunctional prefrontal-thalamic-cerebellar circuitry [J].
Andreasen, NC ;
OLeary, DS ;
Cizadlo, T ;
Arndt, S ;
Rezai, K ;
Ponto, LLB ;
Watkins, GL ;
Hichwa, RD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (18) :9985-9990
[5]
ANDREASEN NC, 2008, BIOL PSYCHI IN PRESS
[6]
Arnsten AFT, 2006, J CLIN PSYCHIAT, V67, P7
[7]
AREA AND VOLUME MEASUREMENT OF POSTERIOR-FOSSA STRUCTURES IN MRI [J].
AYLWARD, EH ;
REISS, A .
JOURNAL OF PSYCHIATRIC RESEARCH, 1991, 25 (04) :159-168
[8]
CEREBELLAR PLAQUES IN FAMILIAL ALZHEIMERS-DISEASE (GERSTMANN-STRAUSSLER-SCHEINKER VARIANT-QUESTIONABLE) [J].
AZZARELLI, B ;
MULLER, J ;
GHETTI, B ;
DYKEN, M ;
CONNEALLY, PM .
ACTA NEUROPATHOLOGICA, 1985, 65 (3-4) :235-246
[9]
Pathological alterations of the climbing fibres of the cerebellum in vascular dementia: A Golgi and electron microscope study [J].
Baloyannis, Stavros J. .
JOURNAL OF THE NEUROLOGICAL SCIENCES, 2007, 257 (1-2) :56-61
[10]
Very late-onset schizophrenia-like psychosis: Clinical and imaging characteristics in comparison with elderly patients with schizophrenia [J].
Barak, Y ;
Aizenberg, D ;
Mirecki, I ;
Mazeh, D ;
Achiron, A .
JOURNAL OF NERVOUS AND MENTAL DISEASE, 2002, 190 (11) :733-736