Scratching behavior in mice induced by the proteinase-activated receptor-2 agonist, SLIGRL-NH2

被引：95

作者：

Shimada, SG ^{[1
]}

Shimada, KA ^{[1
]}

Collins, JG ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Anesthesiol, New Haven, CT 06520 USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2006年 / 530卷 / 03期

关键词：

itch; histamine; pyrilamine; PAR2 (proteinase-activated receptor-2);

D O I：

10.1016/j.ejphar.2005.11.012

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We examined whether the proteinase-activated receptor-2 (PAR2) agonist, H-Ser-Leu-IIe-Gly-Arg-Leu-NiH2 (SLIGRL-NH2), could induce scratching behavior in mice. Intradermal injections of SLIGRL-NH2 (10-50 mu g) evoked dose dependent scratching. This behavior peaked near 5 min and returned to preinjection levels within 30 min. Pretreatment of animals with a histamine H-1 receptor antagonist, pyrilamine, blocked histamine induced scratching, but it had little effect on SLIGRL scratching. Our study suggests that PAR2 mediates histamine independent itch. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：281 / 283

页数：3

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