A Ratiometric Fluorescent Probe for Rapid Detection of Hydrogen Sulfide in Mitochondria

被引：518

作者：

Chen, Yuncong ^{[1
]}

Zhu, Chengcheng ^{[1
]}

Yang, Zhenghao ^{[1
]}

Chen, Junjie ^{[1
]}

He, Yafeng ^{[1
]}

Jiao, Yang ^{[1
]}

He, Weijiang ^{[1
]}

Qiu, Lin ^{[1
]}

Cen, Jiajie ^{[1
]}

Guo, Zijian ^{[1
]}

机构：

[1] Nanjing Univ, Sch Chem & Chem Engn, Inst Coordinat Chem, State Key Lab Coordinat Chem, Nanjing 210093, Jiangsu, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 06期

基金：

中国国家自然科学基金;

关键词：

fluorescence imaging; fluorescent probes; hydrogen sulfide; mitochondria; ratiometric probes; VASORELAXANT; TISSUE; H2S;

D O I：

10.1002/anie.201207701

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Quick: An exogenously induced quick increase of the H2S concentration (80 s) in MCF-7 cells can be visualized by ratiometric imaging using a new probe (CouMC) that can target mitochondria. CouMC was constructed by combining merocyanine and coumarin fluorophores. The selective nucleophilic addition of HS- to the merocyanine derivative at neutral pH is crucial for the rapid H2S detection. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

收藏

页码：1688 / 1691

页数：4

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