Engineering fatty acid biosynthesis in microalgae for sustainable biodiesel

被引：93

作者：

Blatti, Jillian L. ^{[1
]}

Michaud, Jennifer ^{[1
]}

Burkart, Michael D. ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2013年 / 17卷 / 03期

基金：

美国能源部; 美国国家科学基金会;

关键词：

ACYL CARRIER PROTEIN; ACETYL-COA CARBOXYLASE; BIOFUEL; COENZYME; ALGAE; CYANOBACTERIA; ACCUMULATION; SYNTHETASE; FEEDSTOCKS; DIVERSITY;

D O I：

10.1016/j.cbpa.2013.04.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Microalgae are a promising feedstock for biodiesel and other liquid fuels due to their fast growth rate, high lipid yields, and ability to grow in a broad range of environments. However, many microalgae achieve maximal lipid yields only under stress conditions hindering growth and providing compositions not ideal for biofuel applications. Metabolic engineering of algal fatty acid biosynthesis promises to create strains capable of economically producing fungible and sustainable biofuels. The algal fatty acid biosynthetic pathway has been deduced by homology to bacterial and plant systems, and much of our understanding is gleaned from basic studies in these systems. However, successful engineering of lipid metabolism in algae will necessitate a thorough characterization of the algal fatty acid synthase (FAS) including protein-protein interactions and regulation. This review describes recent efforts to engineer fatty acid biosynthesis toward optimizing microalgae as a biodiesel feedstock.

引用

页码：496 / 505

页数：10

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