Identification of chemical-weapons-related compounds in decontamination solutions and other matrices by multiple chromatographic techniques

被引：36

作者：

Creasy, WR ^{[1
]}

Stuff, JR ^{[1
]}

Williams, B ^{[1
]}

Morrissey, K ^{[1
]}

Mays, J ^{[1
]}

Duevel, R ^{[1
]}

Durst, HD ^{[1
]}

机构：

[1] EDGEWOOD RES DEV & ENGN CTR,RES & TECHNOL DIRECTORATE,EDGEWOOD AREA,ABERDEEN PROVING GROUND,MD 21010

来源：

JOURNAL OF CHROMATOGRAPHY A | 1997年 / 774卷 / 1-2期

关键词：

warfare agents;

D O I：

10.1016/S0021-9673(97)00155-6

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Several applications have arisen for the high confidence identification of chemical weapons agents and related compounds in toxic waste or other complex matrices. Three examples of analysis of agents or byproducts are presented: GA (ethyl N,N-dimethylphosphoramidocyanidate, or tabun) and synthetic byproducts in an complex organic liquid solution; HD [bis(2-chloroethyl)sulfide, or mustard gas] in a decontamination solution; and VX (S,2-diisopropylaminoethyl ethyl methylphosphonothioate) and a toxic hydrolysis product (S,2-diisopropylaminoethyl methylphosphonothioic acid, also known as EA-2192). Multiple chromatographic methods were used to unequivocally identify low concentrations of agent with high confidence, including results from gas chromatographic analysis with mass spectral detection (with electron impact or chemical ionization), infrared detection, atomic emission detection and flame photometric detection, as well as liquid chromatography-tandem mass spectrometry.

引用

页码：253 / 263

页数：11

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