Calx, a Na-Ca exchanger gene of Drosophila melanogaster

被引：168

作者：

Schwarz, EM ^{[1
]}

Benzer, S ^{[1
]}

机构：

[1] CALTECH,DIV BIOL,PASADENA,CA 91125

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1997年 / 94卷 / 19期

关键词：

D O I：

10.1073/pnas.94.19.10249

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have cloned Calx, a gene that encodes a Na-Ca exchanger of Drosophila melanogaster. Calx encodes two repeated motifs, Calx-alpha and Calx-beta, that overlap domains required for exchanger activity and regulation, Calx has multiple transcripts in adults, including at least one expressed in the retina. The Calx genomic locus comprises greater than or equal to 35 kb between the Atp alpha and rudimentary-like genes in chromosomal region 93B. In Xenopus oocytes, microinjected Calx cRNA induces calcium uptake like that of its homolog, the 3Na(+)-1Ca(2+) exchanger of mammalian heart, Implications of Calx-alpha motifs for the mechanism of Na-Ca exchange are discussed.

引用

页码：10249 / 10254

页数：6

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