Genetic support for the role of the NLRP3 inflammasome in psoriasis susceptibility

被引：127

作者：

Carlstrom, Maria ^{[1
]}

Ekman, Anna-Karin ^{[1
]}

Petersson, Stina ^{[1
]}

Soderkvist, Peter ^{[2
]}

Enerback, Charlotta ^{[1
]}

机构：

[1] Linkoping Univ, Div Cell Biol & Dermatol, Dept Clin & Expt Med, Ingrid Asp Psoriasis Res Ctr,Fac Hlth Sci, SE-58185 Linkoping, Sweden

[2] Linkoping Univ, Div Cell Biol, Dept Clin & Expt Med, Fac Hlth Sci, SE-58185 Linkoping, Sweden

来源：

EXPERIMENTAL DERMATOLOGY | 2012年 / 21卷 / 12期

关键词：

CARD8; NLRP3; psoriasis; GENOME-WIDE ASSOCIATION; COLD AUTOINFLAMMATORY SYNDROME; CROHNS-DISEASE; RHEUMATOID-ARTHRITIS; PATTERN-RECOGNITION; COMMON VARIANTS; NO ASSOCIATION; BOWEL-DISEASE; HLA-C; CARD8;

D O I：

10.1111/exd.12049

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100227 [皮肤病学];

摘要：

NACHT leucine-rich repeat- and PYD-containing (NLRP)3 protein controls the inflammasome by regulating caspase-1 activity and interleukin (IL)-1 beta processing. The contribution of IL-1 beta in the pathogenesis of psoriasis is well recognized. Polymorphisms in NLRP3 and caspase recruitment domaincontaining protein (CARD)8, a negative regulator of caspase-1 activity, have been associated with susceptibility to common inflammatory diseases, such as Crohn's disease and rheumatoid arthritis. To investigate the role for genetic variants in the NLRP3 inflammasome in psoriasis susceptibility. In a patient sample comprising 1988 individuals from 491 families and 1002 healthy controls, genotypes for four selected single-nucleotide polymorphisms (SNPs) in NLRP3 (three SNPs) and CARD8 (one SNP) were determined by TaqMan (R) Allelic Discrimination. Using the transmission disequilibrium test (TDT), a significant increase in the transmission of the NLRP3 rs10733113G genotype to a subgroup of patients with more widespread psoriasis was demonstrated (P = 0.015). Using logistic regression analysis in 741 patients with psoriasis and 1002 controls, the CARD8 rs2043211 genotype was significantly different in cases and controls in overall terms [OR 1.3 (1.11.5), P = 0.004] and for both genders. Our data support the hypothesis that the inflammasome plays a role in psoriasis susceptibility.

引用

页码：932 / 937

页数：6

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