Helicobacter pylori Protection Against Reflux Esophagitis

被引：43

作者：

Ashktorab, Hassan ^{[1
]}

Entezari, Omid ^{[1
]}

Nouraie, Mehdi ^{[2
]}

Dowlati, Ehsan ^{[1
]}

Frederick, Wayne ^{[1
]}

Woods, Alfreda ^{[1
]}

Lee, Edward ^{[3
]}

Brim, Hassan ^{[3
]}

Smoot, Duane T. ^{[4
]}

Ghadyari, Firoozeh ^{[1
]}

Kamangar, Farin ^{[5
]}

Razjouyan, Hadie ^{[1
]}

机构：

[1] Howard Univ, Howard Univ Hosp, Dept Med, Ctr Canc, Washington, DC 20059 USA

[2] Howard Univ, Ctr Sickle Cell Dis, Dept Med, Washington, DC 20059 USA

[3] Howard Univ, Coll Med, Dept Pathol, Washington, DC 20059 USA

[4] Meharry Med Coll, Dept Internal Med, Nashville, TN 37208 USA

[5] Morgan State Univ, Sch Community Hlth & Policy, Baltimore, MD 21239 USA

来源：

DIGESTIVE DISEASES AND SCIENCES | 2012年 / 57卷 / 11期

关键词：

H; pylori; Reflux esophagitis; African Americans; GASTROESOPHAGEAL-REFLUX; EROSIVE ESOPHAGITIS; BARRETTS-ESOPHAGUS; GERD SYMPTOMS; RISK-FACTORS; CANCER-RISK; INFECTION; DISEASE; PREVALENCE; ERADICATION;

D O I：

10.1007/s10620-012-2349-3

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Negative association has been reported between presence of Helicobacter pylori and developing gastroesophageal reflux disease (GERD) and its complications. The aim of this study was to determine whether H. pylori (HP) can be protective against GERD in an African American (AA) population. From 2004 to 2007, we studied 2,020 cases; esophagitis (58), gastritis (1,558), both esophagitis and gastritis (363) and a normal control group (41). We collected their pathology and endoscopy unit reports. HP status was determined based on staining of gastric biopsy. HP data was available for 79 % (1,611) of the cases. The frequency of HP positivity in gastritis patients was 40 % (506), in esophagitis patients 4 % and in normal controls 34 % (11), while HP was positive in 34 % of the patients with both esophagitis and gastritis. After adjusting for effects of age and sex, odds ratio of HP was 0.06 (95 % CI 0.01-0.59; P value = 0.01) for the esophagitis group versus the normal group. Our results show H. pylori has a significant negative association with esophagitis in AAs which may point to a protective role of H. pylori in the pathogenesis of esophagitis. In addition, H. pylori may be the reason for the low GERD complications in AAs.

引用

页码：2924 / 2928

页数：5

共 39 条

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