Effect of Shear Force on Intervertebral Disc (IVD) Degeneration: An In Vivo Rat Study

被引：71

作者：

Kim, Jaehyun ^{[1
,2
]}

Yang, Seok-Jo ^{[3
]}

Kim, Hyunchul ^{[4
]}

Kim, Yoonsang ^{[5
]}

Park, Joon B. ^{[1
]}

DuBose, Candis ^{[1
]}

Lim, Tae-Hong ^{[1
]}

机构：

[1] Univ Iowa, Dept Biomed Engn, Seamans Ctr 1402, Iowa City, IA 52242 USA

[2] Wake Forest Univ, Winston Salem, NC 27157 USA

[3] Chungnam Natl Univ, Dept Mechatron Engn, Taejon, South Korea

[4] Univ Maryland, Dept Bioengn, College Pk, MD 20742 USA

[5] Univ Illinois, Div Epidemiol & Biostat, Chicago, IL 60612 USA

来源：

ANNALS OF BIOMEDICAL ENGINEERING | 2012年 / 40卷 / 09期

关键词：

Low back pain; Biomechanics; Animal model; LOAD-CARRYING CAPACITY; LOW-BACK-PAIN; LUMBAR SPINE; FOLLOWER LOAD; TAIL MODEL; CYCLIC COMPRESSION; NUCLEUS PULPOSUS; IMMOBILIZATION; PROTEOGLYCANS; EXPRESSION;

D O I：

10.1007/s10439-012-0570-z

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

Mechanical stress on the intervertebral disc (IVD) may contribute significantly to IVD degeneration, although its pathomechanism has not been fully understood. The purpose of this study was to test the hypothesis that sustained application of static shear force would result in IVD degeneration with minimum injury. We applied shear force on the rat lumbar spine (L5-L6) using a custom-designed loading device for 1 or 2 weeks. Degenerative changes such as nucleus pulposus cavity loss and border disruption were observed from the histology sections, indicating that the application of sustained dorsoventral shear force on the L6 vertebra induced degeneration of the IVDs in L5-L6 and adjacent levels of motion segment in 1 and 2 weeks. The findings of the present study could be useful for gaining a more relevant understanding of the biomechanical load factors of IVD degeneration not only for enabling better therapeutic interventions but also reducing the risk of low back injury.

引用

页码：1996 / 2004

页数：9

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