Characterization of new mutations in pyrazinamide-resistant strains of Mycobacterium tuberculosis and identification of conserved regions important for the catalytic activity of the pyrazinamidase PncA

被引：89

作者：

Lemaitre, N

Sougakoff, W

Truffot-Pernot, C

Jarlier, V

机构：

[1] Univ Paris 06, Fac Med Pitie Salpetriere, Lab Rech Mol Antibiot, F-75634 Paris 13, France

[2] Grp Hosp Pitie Salpetriere, Ctr Natl Reference Surveillance Bacteriol Infect, F-75634 Paris, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1999年 / 43卷 / 07期

关键词：

D O I：

10.1128/AAC.43.7.1761

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A new set of mutations, including transposition of the insertion sequence IS6110, was identified in the pncA gene from 19 pyrazinamide-resistant Mycobacterium tuberculosis strains. Alignment of the PncA protein from M. tuberculosis with homologous proteins from different bacterial species revealed three highly conserved regions in PncA which may play an important role in the processing of pyrazinamide.

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页码：1761 / 1763

页数：3

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