Linkage disequilibrium:: what history has to tell us

被引：354

作者：

Nordborg, M ^{[1
]}

Tavaré, S ^{[1
]}

机构：

[1] Univ So Calif, Los Angeles, CA 90089 USA

来源：

TRENDS IN GENETICS | 2002年 / 18卷 / 02期

关键词：

D O I：

10.1016/S0168-9525(02)02557-X

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Linkage disequilibrium has become important in the context of gene mapping. We argue that to understand the pattern of association between alleles at different loci, and of DNA sequence polymorphism in general, it is useful first: to consider the underlying genealogy of the chromosomes. The stochastic process known as the coalescent is a convenient way to model such genealogies, and in this paper we set out the theory behind the coalescent and its implications for understanding linkage disequilibrium.

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页码：83 / 90

页数：8

相关论文

共 64 条

[1] Extent and distribution of linkage disequilibrium in three genomic regions [J].

Abecasis, GR ;

Noguchi, E ;

Heinzmann, A ;

Traherne, JA ;

Bhattacharyya, S ;

Leaves, NI ;

Anderson, GG ;

Zhang, YM ;

Lench, NJ ;

Carey, A ;

Cardon, LR ;

Moffatt, MF ;

Cookson, WOC .

AMERICAN JOURNAL OF HUMAN GENETICS, 2001, 68 (01) :191-197

[2]

[Anonymous], HDB STAT GENETICS

[3]

[Anonymous], 1998, COMMUN STAT STOCH MO, DOI [10.1080/15326349808807471, DOI 10.1080/15326349808807471]

[4]

Balding D., 2001, HDB STAT GENETICS, P179, DOI DOI 10.2307/2419615

[5] A look at linkage disequilibrium [J].

Boehnke, M .

NATURE GENETICS, 2000, 25 (03) :246-247

[6] Association study designs for complex diseases [J].

Cardon, LR ;

Bell, JI .

NATURE REVIEWS GENETICS, 2001, 2 (02) :91-99

[7] Linkage-disequilibrium mapping without genotyping [J].

Cheung, VG ;

Gregg, JP ;

Gogolin-Ewens, KJ ;

Bandong, J ;

Stanley, CA ;

Baker, L ;

Higgins, MJ ;

Nowak, NJ ;

Shows, TB ;

Ewens, WJ ;

Spielman, RS .

NATURE GENETICS, 1998, 18 (03) :225-230

[8]

Clare AS, 1998, J MAR BIOTECHNOL, V6, P3

[9] Linkage disequilibrium mapping of disease susceptibility genes in human populations [J].

Clayton, D .

INTERNATIONAL STATISTICAL REVIEW, 2000, 68 (01) :23-43

[10] Genetic epidemiology of single-nucleotide polymorphisms [J].

Collins, A ;

Lonjou, C ;

Morton, NE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (26) :15173-15177

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