LTP in the lateral perforant path is beta-adrenergic receptor-dependent

被引：81

作者：

Bramham, CR ^{[1
]}

BacherSvendsen, K ^{[1
]}

Sarvey, JM ^{[1
]}

机构：

[1] UNIFORMED SERV UNIV HLTH SCI, DEPT PHARMACOL, BETHESDA, MD 20814 USA

来源：

NEUROREPORT | 1997年 / 8卷 / 03期

关键词：

beta-adrenergic receptor; dentate gyrus; hippocampus; learning and memory; long-term depression; long-term potentiation; norepinephrine;

D O I：

10.1097/00001756-199702100-00028

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

NOREPINEPHRINE induces an activity-independent long-lasting depression of synaptic transmission in the lateral perforant path input to dentate granule cells, whereas high frequency stimulation induces activity-dependent long-term potentiation (LTP). We investigated the role of endogenous activation of beta-adrenergic receptors in LTP of the lateral and medial perforant paths under conditions affording selective stimulation of these pathways in the rat hippo-campal slice. Propranolol (1 mu M), a beta-receptor antagonist, blocked LTP induction of both lateral and medial perforant path-evoked field excitatory postsynaptic potentials. The results indicate a broad requirement for norepinephrine in different types of synaptic plasticity, including activity-independent depression an activity-dependent LTP in the lateral perforant path.

引用

页码：719 / 724

页数：6

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