Synthesis of natural products containing a C-P bond

Since the original discovery in 1959 of AEP by Horiguchi and Kandatsu, over 20 distinct classes of natural products have been isolated which contain a C-P bond. The diverse biological activities associated with these molecules has driven aggressive synthetic programs. Syntheses have been devised for the vast majority of these which have not only validated the structure assignments but also enabled examination of the structure-activity relationships.