Telomeres: has cancer's Achilles' heel been exposed?

被引：14

作者：

Zumstein, LA ^{[1
]}

Lundblad, V

机构：

[1] Introgen Therapeut Inc, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA

来源：

NATURE MEDICINE | 1999年 / 5卷 / 10期

关键词：

D O I：

10.1038/13451

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Telomerase allows cells to grow indefinitely, and is expressed in the majority of human cancers. New data suggest, however, that telomere maintenance might be a stumbling block on the path to immortalization and that inhibition of telomere replication can attenuate human cancer cell growth (pages 1164–1170) .

引用

收藏

页码：1129 / 1130

页数：2

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