Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease

被引：351

作者：

Tregouet, David-Alexandre ^{[1
]}

Koenig, Inke R. ^{[2
]}

Erdmann, Jeanette ^{[3
]}

Munteanu, Alexandru ^{[1
]}

Braund, Peter S. ^{[4
]}

Hall, Alistair S. ^{[5
]}

Grosshennig, Anika ^{[2
,3
]}

Linsel-Nitschke, Patrick ^{[3
]}

Perret, Claire ^{[1
]}

DeSuremain, Maylis ^{[1
]}

Meitinger, Thomas ^{[6
]}

Wright, Ben J. ^{[7
]}

Preuss, Michael ^{[2
]}

Balmforth, Anthony J. ^{[5
]}

Ball, Stephen G. ^{[5
]}

Meisinger, Christa ^{[6
]}

Germain, Cecile ^{[8
]}

Evans, Alun ^{[9
]}

Arveiler, Dominique ^{[10
]}

Luc, Gerald ^{[11
]}

Ruidavets, Jean-Bernard ^{[12
]}

Morrison, Caroline ^{[13
]}

van der Harst, Pim ^{[4
]}

Schreiber, Stefan ^{[14
]}

Neureuther, Katharina ^{[15
]}

Schaefer, Arne ^{[14
]}

Bugert, Peter ^{[16
]}

El Mokhtari, Nour E. ^{[14
]}

Schrezenmeir, Juergen ^{[17
]}

Stark, Klaus ^{[15
]}

Rubin, Diana ^{[17
]}

Wichmann, H-Erich ^{[6
]}

Hengstenberg, Christian ^{[15
]}

Ouwehand, Willem ^{[18
]}

Ziegler, Andreas ^{[2
]}

Tiret, Laurence ^{[1
]}

Thompson, John R. ^{[7
]}

Cambien, Francois ^{[1
]}

Schunkert, Heribert ^{[3
]}

Samani, Nilesh J. ^{[4
]}

机构：

[1] Univ Paris 06, INSERM, UMR S 525, F-75013 Paris, France

[2] Med Univ Lubeck, Inst Med Biometrie & Stat, D-23538 Lubeck, Germany

[3] Med Univ Lubeck, Med Klin 2, D-23538 Lubeck, Germany

[4] Univ Leicester, Clin Sci Wing, Glenfield Hosp, Dept Cardiovasc Sci, Leicester LE3 9QP, Leics, England

[5] Univ Leeds, LIGHT, Leeds LS1 3EX, W Yorkshire, England

[6] Deutsch Forschungszentrum Umwelt & Gesundheit, Helmholtz Zentrum Munchen, Inst Humangenet, D-85764 Neuherberg, Germany

[7] Univ Leicester, Dept Hlth Sci & Genet, Leicester LE1 7RH, Leics, England

[8] Univ Paris 11, CNRS, UMR S 8623, Rech Informat Lab, F-91403 Orsay, France

[9] Queens Univ Belfast, Dept Epidemiol & Publ Hlth, Belfast BT7 1NN, Antrim, North Ireland

[10] Multinat MONItoring Trends & Determinants CArdiov, Fac Med, Lab Epidemiol & Sante Publ EA1801, F-67085 Strasbourg, France

[11] Univ Lille 2, Pasteur Inst Lille, INSERM, U545, F-59019 Lille, France

[12] MONICA Toulouse, Fac Med, INSERM, U518, F-31073 Toulouse, France

[13] Glasgow Royal Infirm, MONICA Project, Glasgow G4 0SF, Lanark, Scotland

[14] Univ Kiel, Inst Klin Mol Biol, D-24105 Kiel, Germany

[15] Univ Regensburg, Klin & Poliklin Innere Med 2, D-93042 Regensburg, Germany

[16] Univ Heidelberg, Med Fac Mannheim, Inst Transfus Med & Immunol, Mol Biol Lab, D-69117 Heidelberg, Germany

[17] Inst Physiol & Biochem Ernahrung, Bundesforsch Sanstalt Ernahrung & Lebensmittel, D-24121 Kiel, Germany

[18] Univ Cambridge, Dept Haematol, Cambridge CB2 2PT, England

来源：

NATURE GENETICS | 2009年 / 41卷 / 03期

基金：

英国惠康基金;

关键词：

APOLIPOPROTEIN(A) GENE; MYOCARDIAL-INFARCTION; LIPOPROTEIN(A) LEVELS; HEART-DISEASE; POLYMORPHISMS; ECTIM;

D O I：

10.1038/ng.314

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We identify the SLC22A3-LPAL2-LPA gene cluster as a strong susceptibility locus for coronary artery disease (CAD) through a genome-wide haplotype association (GWHA) study. This locus was not identified from previous genome-wide association (GWA) studies focused on univariate analyses of SNPs. The proposed approach may have wide utility for analyzing GWA data for other complex traits.

引用

页码：283 / 285

页数：3

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