Racial background is a determinant of average warfarin dose required to maintain the INR between 2•0 and 3•0

被引:63
作者
Blann, A [1 ]
Hewitt, J [1 ]
Siddiqui, F [1 ]
Bareford, D [1 ]
机构
[1] City Hosp, Dept Haematol, Birmingham B18 7QH, W Midlands, England
关键词
warfarin; racial background;
D O I
10.1046/j.1365-2141.1999.01672.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Warfarin is a commonly used prophylactic agent for the prevention of thromboembolic disease. We hypothesized that racial background influenced warfarin dosage, and tested this by recording the international normalized ratio (INR) in 867 patients aged 40-90 routinely passing through our Anticoagulation Service whose target INR was 2-3. Mean (95% confidence interval) dose was 4.1 (4.0-4.2) mg/d in 737 Caucasians. 5.5 (4.9-6.1) mg/d in 72 Asians, and 6.7 (5.8-7.6)mg/d in 58 Afro-Caribbeans (P<0.05) between each group). In a subgroup of 302 (41 Asians, 22 Afro-Caribbeans. 239 Caucasians), body mass index did not influence warfarin use. Despite small numbers, we conclude that racial background, but not body mass index, is a determinant of warfarin dosage. The reasons for this could be genetic, cultural (diet related), or both.
引用
收藏
页码:207 / 209
页数:3
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