Association of the rs7903146 single nucleotide polymorphism at the Transcription Factor 7-like 2 (TCF7L2) locus with type 2 diabetes in Brazilian subjects

被引：23

作者：

Barra, Gustavo Barcelos ^{[1
,2
]}

Sanches Dutra, Ludmila Alves ^{[1
]}

Watanabe, Silvia Conde ^{[3
,4
]}

Garcia Costa, Patricia Godoy ^{[1
]}

Marques da Cruz, Patricia Sales ^{[3
]}

Azevedo, Monalisa Ferreira ^{[2
,3
]}

Amato, Angelica Amorim ^{[2
,3
,4
]}

机构：

[1] Inst & Lab Sabin Anal Clin, Unidade Biol Mol, Brasilia, DF, Brazil

[2] Univ Brasilia, Programa Posgrad Ciencias Saude, BR-70910900 Brasilia, DF, Brazil

[3] Univ Brasilia, Hosp Univ Brasilia, BR-70910900 Brasilia, DF, Brazil

[4] Univ Brasilia, Fac Ciencias Saude, Lab Farmacol Mol, BR-70910900 Brasilia, DF, Brazil

来源：

ARQUIVOS BRASILEIROS DE ENDOCRINOLOGIA E METABOLOGIA | 2012年 / 56卷 / 08期

关键词：

TCF7L2; single nucleotide polymorphism; type; 2; diabetes; rs7903146; GENOME-WIDE ASSOCIATION; INSULIN-SECRETION; GENE-EXPRESSION; BETA-CELLS; SUSCEPTIBILITY LOCI; RISK; POPULATION; VARIANTS; GLUCOSE; METAANALYSIS;

D O I：

10.1590/S0004-27302012000800003

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Objective: To investigate the association of the T allele of the single nucleotide polymorphism (SNP) rs7903146 of TCF7L2 with the occurrence of T2D in a sample of subjects followed up at the Brasilia University Hospital. Subjects and methods: The SNP rs7903146 of TCF7L2 was genotyped by allele-specific PCR in 113 patients with known T2D and in 139 non-diabetic controls in Brasilia, Brazil. Results: We found that the T allele of the SNP rs7903146 of TCF7L2 was significantly associated with T2D risk (odds ratio of 3.92 for genotype TT in the recessive genetic model, p = 0.004 and 1.5 for T allele, p = 0.032). Conclusion: These results reinforce previous findings on the consistent association of this genetic factor and the risk of T2D in populations of diverse ethnic backgrounds. Arq Bras Endocrinol Metab. 2012;56(8):479-84

引用

页码：479 / 484

页数：6

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