Preparation of octenyl succinic anhydride-modified debranched starch vesicles for loading of hydrophilic functional ingredients

被引：40

作者：

Chang, Ranran ^{[1
]}

Xiong, Liu ^{[1
]}

Li, Man ^{[1
]}

Chen, Haihua ^{[1
]}

Xiao, Junxia ^{[1
]}

Wang, Shiqing ^{[1
]}

Qiu, Lizhong ^{[2
]}

Bian, Xiliang ^{[2
]}

Sun, Chunrui ^{[2
]}

Sun, Qingjie ^{[1
]}

机构：

[1] Qingdao Agr Univ, Coll Food Sci & Engn, 700 Changcheng Rd, Qingdao 266109, Shandong, Peoples R China

[2] Zhucheng Xingmao Corn Developing Co Ltd, Weifang 262200, Shandong, Peoples R China

来源：

FOOD HYDROCOLLOIDS | 2019年 / 94卷

基金：

中国国家自然科学基金;

关键词：

Polymersomes; Characteristics; Self-assemble; Amphiphilic; Insulin; STRUCTURAL-PROPERTIES; HYBRID NANOPARTICLES; POLYMERIC MICELLES; BLOCK-COPOLYMERS; DELIVERY;

D O I：

10.1016/j.foodhyd.2019.04.006

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

Vesicles have been attracting a great deal of interest because of their great potential for health food, medicine, and biotechnology applications. This study aimed to develop a new type of debranched starch (DBS) vesicle for loading and delivering active components. DBS with a low degree of polymerization (6.75) and good water solubility was modified with octenyl succinic anhydride (OSA) to obtain an amphiphilic polymer. Both the Fourier transform infrared spectroscopy and the H-1 nuclear magnetic resonance results confirmed the successful synthesis of amphiphilic OSA-DBS polymers. The OSA-DBS spontaneously formed 10-30 nm vesicles in a water system, as measured by transmission electron microscopy. The vesicles were relatively stable at different temperatures, pH values, and ionic strengths. Insulin was used as a hydrophilic functional ingredient model. The insulin-loaded vesicles exhibited a high loading content (similar to 13.36%). These OSA-DBS vesicles have potential utility as advanced carriers in the health food and biomedical industries.

引用

页码：546 / 552

页数：7

共 41 条

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