Characterization of a mutation in the parE gene that confers fluoroquinolone resistance in Streptococcus pneumoniae

被引：105

作者：

Perichon, B ^{[1
]}

Tankovic, J ^{[1
]}

Courvalin, P ^{[1
]}

机构：

[1] HOP HENRI MONDOR,SERV BACTERIOL VIROL HYG,F-94010 CRETEIL,FRANCE

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1997年 / 41卷 / 05期

关键词：

D O I：

10.1128/AAC.41.5.1166

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We report a mutation in the parE genes of ho in vitro mutants of Streptocaccus pneunoniae responsible for low-level resistance to fluoroquinolones. Sequential acquisition of mutations in parE and gyr.4 lends to higher levels of resistance. This confirms that topoisomerase IV is the primary target of fluoroquinolones in S. pneumoniae.

引用

页码：1166 / 1167

页数：2

共 14 条

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