Gamma interferon fails to induce expression of indoleamine 2,3-dioxygenase and does not control the growth of Chlamydophila abortus in BeWo trophoblast cells

被引：23

作者：

Entrican, G

Wattegedera, S

Chui, M

Oemar, L

Rocchi, M

McInnes, C

机构：

[1] Moredun Res Inst, Edinburgh EH26 0PZ, Midlothian, Scotland

[2] Univ Edinburgh, Dept Vet Clin Studies, Roslin EH25 9RG, Midlothian, Scotland

来源：

INFECTION AND IMMUNITY | 2002年 / 70卷 / 05期

关键词：

D O I：

10.1128/IAI.70.5.2690-2693.2002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The BeWo trophoblast cell line does not constitutively express the tryptophan degrading enzyme indolamine 2,3-dioxygenase (IDO), nor can IDO expression be induced by gamma interferon. This correlates with the inability of BeWo cells to control the growth of Chlamydophila abortus, in contrast to effects observed in HeLa cells treated with gamma interferon.

引用

收藏

页码：2690 / 2693

页数：4

相关论文

共 26 条

[1] Much IDO about pregnancy [J].

Bonney, EA ;

Matzinger, P .

NATURE MEDICINE, 1998, 4 (10) :1128-1129

[2] A role for tryptophan in immune control of chlamydial abortion in sheep [J].

Brown, J ;

Howie, SEM ;

Entrican, G .

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 2001, 82 (1-2) :107-119

[3] SINGLE-STEP METHOD OF RNA ISOLATION BY ACID GUANIDINIUM THIOCYANATE PHENOL CHLOROFORM EXTRACTION [J].

CHOMCZYNSKI, P ;

SACCHI, N .

ANALYTICAL BIOCHEMISTRY, 1987, 162 (01) :156-159

[4]

Clark DA, 1998, J IMMUNOL, V160, P545

[5] The Th2 cytokine environment of the placenta [J].

Dealtry, GB ;

O'Farrell, MK ;

Fernandez, N .

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2000, 123 (02) :107-119

[6]

ELLIS SA, 1990, J IMMUNOL, V144, P731

[7] Chlamydial infection in sheep: immune control versus fetal pathology [J].

Entrican, G ;

Buxton, D ;

Longbottom, D .

JOURNAL OF THE ROYAL SOCIETY OF MEDICINE, 2001, 94 (06) :273-277

[8] INTERFERON-GAMMA RECEPTORS ON HUMAN GESTATIONAL CHORIOCARCINOMA CELL-LINES - QUANTITATIVE AND FUNCTIONAL-STUDIES [J].

FULOP, V ;

STELLER, MA ;

BERKOWITZ, RS ;

ANDERSON, DJ .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1992, 167 (02) :524-530

[9] RECOMBINANT OVINE INTERFERON-GAMMA INHIBITS THE MULTIPLICATION OF CHLAMYDIA-PSITTACI IN OVINE CELLS [J].

GRAHAM, SP ;

JONES, GE ;

MACLEAN, M ;

LIVINGSTONE, M ;

ENTRICAN, G .

JOURNAL OF COMPARATIVE PATHOLOGY, 1995, 112 (02) :185-195

[10] Lack of detectable major histocompatibility complex class II A beta-chain messenger ribonucleic acid in placentas of interferon-gamma- and 5-azacytidine-treated mice [J].

Gustafsson, E ;

Arvola, M ;

Brunsberg, U ;

Mattsson, A ;

Mattsson, R .

BIOLOGY OF REPRODUCTION, 1997, 57 (04) :715-722