GABAB receptor agonist baclofen improves methamphetamine-induced cognitive deficit in mice

被引：42

作者：

Arai, Sawako ^{[2
]}

Takuma, Kazuhiro ^{[2
]}

Mizoguchi, Hiroyuki ^{[2
,3
]}

Ibi, Daisuke ^{[2
]}

Nagai, Taku ^{[1
]}

Kamei, Hiroyuki ^{[4
]}

Kim, Hyoung-Chun ^{[5
]}

Yamada, Kiyofumi ^{[1
,2
,6
]}

机构：

[1] Nagoya Univ, Grad Sch Med, Dept Neuropsychopharmacol & Hosp Pharm, Nagoya, Aichi 4668560, Japan

[2] Kanazawa Univ, Grad Sch Nat Sci & Technol, Div Life Sci, Lab Neuropsychopharmacol, Kanazawa, Ishikawa 9201192, Japan

[3] Nagoya Univ, Environm Med Res Inst, Futurist Environm Simulat Ctr, Nagoya, Aichi 4648601, Japan

[4] Meijo Univ, Grad Sch Pharmaceut Sci, Fac Pharm, Lab Clin Pharm Practice & Hlth Care Management, Nagoya, Aichi 4688503, Japan

[5] Kangwon Natl Univ, Coll Pharm, Neuropsychopharmacol & Toxicol Program, Chunchon 200701, South Korea

[6] JST, CREST, Nagoya, Aichi 4668560, Japan

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2009年 / 602卷 / 01期

关键词：

Baclofen; Cognitive deficit; Methamphetamine; Schizophrenia; VENTRAL TEGMENTAL AREA; RECOGNITION MEMORY; NUCLEUS-ACCUMBENS; DOPAMINE NEURONS; WORKING-MEMORY; SCHIZOPHRENIA; IMPAIRMENT; AMPHETAMINE; SENSITIZATION; CLOZAPINE;

D O I：

10.1016/j.ejphar.2008.10.065

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In this study, we investigated the effects of GABA(A) and GABA(B) receptor agonists on the methamphetamine-induced impairment of recognition memory in mice. Repeated treatment with methamphetamine at a dose of 1 mg/kg for 7 days induced an impairment of recognition memory. Baclofen, a GABA(B) receptor agonist, ameliorated the repeated methamphetamine-induced cognitive impairment, although gaboxadol, a GABA(A) receptor agonist, had no significant effect. GABA(B) receptors may constitute a putative new target in treating cognitive deficits in patients suffering from schizophrenia, as well as methamphetamine psychosis. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：101 / 104

页数：4

共 26 条

[1] Involvement of Pallidotegmental Neurons in Methamphetamine- and MK-801-Induced Impairment of Prepulse Inhibition of the Acoustic Startle Reflex in Mice: Reversal by GABAB Receptor Agonist Baclofen [J].