New natural sesquiterpenes as modulators of daunomycin resistance in a multidrug-resistant Leishmania tropica line

被引：54

作者：

Pérez-Victoria, JM

Tincusi, BM

Jiménez, IA

Bazzocchi, IL

Gupta, MP

Castanys, S

Gamarro, F

Ravelo, AG

机构：

[1] CSIC, Inst Parasitol & Biomed Lopez Neyra, Granada 18001, Spain

[2] Univ La Laguna, Inst Bioorgan Antonio Gonzalez, La Laguna 38206, Tenerife, Spain

[3] Univ Panama, Fac Farm, CIFLORPAN, Panama City, Panama

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1999年 / 42卷 / 21期

关键词：

D O I：

10.1021/jm991066b

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The effects produced by nine dihydro-beta-agarofuran sesquiterpenes isolated from Crossopetalum tonduzii (1-8) and Maytenus macrocarpa (9) (Celastraceae) on the reversion of the resistant phenotype on a multidrug-resistant Leishmania line and their binding to recombinant C-terminal nucleotide-binding domain of Leishmania P-glycoprotein-like transporter were studied. The structures of the new compounds (1-5) were elucidated by spectroscopic methods, including H-1-C-13 heteronuclear correlation (HMQC), long-range correlation spectra with inversal detection (HMBC), ROESY experiments, and chemical correlations. The absolute configuration of one of them (1) was determined by CD studies. The structure-activity relationship is discussed.

引用

页码：4388 / 4393

页数：6

共 32 条

[1]

BRUNING R, 1978, PHYTOCHEMISTRY, V17, P1821, DOI 10.1016/S0031-9422(00)88719-1

[2]

CHAVEZ H, UNPUB

[3] Altered drug membrane permeability in a multidrug resistant Leishmania tropica line [J].