Emerging trends in enzyme inhibition by multivalent nanoconstructs

被引：76

作者：

Kanfar, Nasreddine ^{[1
]}

Bartolami, Eline ^{[1
]}

Zelli, Renaud ^{[1
]}

Marra, Alberto ^{[1
]}

Winum, Jean-Yves ^{[1
]}

Ulrich, Sebastien ^{[1
]}

Dumy, Pascal ^{[1
]}

机构：

[1] Univ Montpellier, UMR CNRS 5247, ENSCM, IBMM, 8 Rue Ecole Normale, F-34296 Montpellier 5, France

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 39期

关键词：

DYNAMIC COMBINATORIAL CHEMISTRY; MOLECULE-DRUG CONJUGATE; CARBONIC-ANHYDRASE IX; GLYCOSIDASE INHIBITION; INFLUENZA-VIRUS; DNA COMPLEXATION; CHEMICAL-BIOLOGY; ANTIINFLUENZA EVALUATION; AMPHIPHILIC DENDRIMERS; BIVALENT INHIBITION;

D O I：

10.1039/c5ob01405k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Multivalent nanoconstructs, extensively used for enhancing the recognition of biomolecular targets, have been recently exploited for enzyme inhibition showing interesting properties such as improvement of inhibitory potency and selectivity. We review herein the recent results highlighting the potential of multivalent nanoconstructs for the inhibition of different enzymes, and the emerging trends in the generation and identification of multivalent clusters as enzyme inhibitors.

引用

收藏

页码：9894 / 9906

页数：13

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