Mast cells and tumour angiogenesis: New insight from experimental carcinogenesis

被引：100

作者：

Crivellato, Enrico ^{[1
]}

Nico, Beatrice ^{[2
]}

Ribatti, Domenico ^{[2
]}

机构：

[1] Univ Udine, Anat Sect, Dept Med & Morphol Res, Sch Med, I-33100 Udine, Italy

[2] Univ Bari, Sch Med, Dept Human Anat & Histol, Bari, Italy

来源：

CANCER LETTERS | 2008年 / 269卷 / 01期

关键词：

angiogenesis; mast cells; tumour;

D O I：

10.1016/j.canlet.2008.03.031

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Histopathologic examination and clinical observations of solid and haematological malignancies indicates mast cells as key host cells in the tumour infiltrate, with important consequence on tumour-associated angiogenesis and tumour growth. Data suggest indeed that tumour-infiltrating mast cells may exert a prominent function in the angiogenic "switch", which is essential for the progression of early tumours. The experimental approach has substantially increased our understanding of the role of tumour-infiltrating mast cells in the process of angiogenesis that accompanies tumour development. This review will focus on the crucial contribution of mast cells in promoting tumour neovascularization as it emerges from the most recent observations of experimental carcinogenesis in in vivo and in vitro models. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：1 / 6

页数：6

共 32 条

[1]

Prostaglandin E2 induces degranulation-independent production of vascular endothelial growth factor by human mast cells [J].

Abdel-Majid, RM ;

Marshall, JS .

JOURNAL OF IMMUNOLOGY, 2004, 172 (02) :1227-1236

[2]

Inflammation and cancer: back to Virchow? [J].

Balkwill, F ;

Mantovani, A .

LANCET, 2001, 357 (9255) :539-545

[3]

Endostatin overexpression inhibits lymphangiogenesis and lymph node metastasis in mice [J].

Brideau, Gaelle ;

Makinen, Markus J. ;

Elamaa, Harri ;

Tu, Hongmin ;

Nilsson, Gunnar ;

Alitalo, Kari ;

Pihlajaniemi, Taina ;

Heljasvaara, Ritva .

CANCER RESEARCH, 2007, 67 (24) :11528-11535

[4]

Impact of Rantes and MCP-1 chemokines on in vivo basophilic cell recruitment in rat skin injection model and their role in modifying the protein and mRNA levels for histidine decarboxylase [J].

Conti, P ;

Pang, XZ ;

Boucher, W ;

Letourneau, R ;

Reale, M ;

Barbacane, RC ;

Thibault, J ;

Theoharides, TC .

BLOOD, 1997, 89 (11) :4120-4127

[5]

Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis [J].

Coussens, LM ;

Raymond, WW ;

Bergers, G ;

Laig-Webster, M ;

Behrendtsen, O ;

Werb, Z ;

Caughey, GH ;

Hanahan, D .

GENES & DEVELOPMENT, 1999, 13 (11) :1382-1397

[6]

MAST-CELLS AND MATRIX DEGRADATION AT SITES OF TUMOR INVASION IN RAT MAMMARY ADENOCARCINOMA [J].

DABBOUS, MK ;

WALKER, R ;

HANEY, L ;

CARTER, LM ;

NICOLSON, GL ;

WOOLLEY, DE .

BRITISH JOURNAL OF CANCER, 1986, 54 (03) :459-465

[7]

Critical protective role of mast cells in a model of acute septic peritonitis [J].

Echtenacher, B ;

Mannel, DN ;

Hultner, L .

NATURE, 1996, 381 (6577) :75-77

[8]

Ehrlich P., 1879, ARCH ANAT PHYSIOL, V3, P166

[9]

Ehrlich P., 1878, THESIS LEIPZIG U

[10]

Mast cell-mediated stimulation of angiogenesis -: Cooperative interaction between A2B and A3 adenosine receptors [J].

Feoktistov, I ;

Ryzhov, S ;

Goldstein, AE ;

Biaggioni, I .

CIRCULATION RESEARCH, 2003, 92 (05) :485-492

← 1 2 3 4 →