MECHANISMS OF DISEASE JAKs and STATs in Immunity, Immunodeficiency, and Cancer

被引:675
作者
O'Shea, John J. [1 ]
Holland, Steven M. [2 ]
Staudt, Louis M. [3 ]
机构
[1] NIAMSD, Mol Immunol & Inflammat Branch, NIH, Bethesda, MD 20892 USA
[2] NIAID, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA
[3] NCI, Metab Branch, NIH, Bethesda, MD 20892 USA
关键词
GENOME-WIDE ASSOCIATION; HYPER-IGE SYNDROME; PLACEBO-CONTROLLED TRIAL; JANUS KINASE INHIBITOR; POLYCYTHEMIA-VERA; MYELOPROLIFERATIVE NEOPLASMS; ESSENTIAL THROMBOCYTHEMIA; ACTIVATING MUTATION; HEMATOPOIETIC STEM; INBORN-ERRORS;
D O I
10.1056/NEJMra1202117
中图分类号
R5 [内科学];
学科分类号
100201 [内科学];
摘要
[No abstract available]
引用
收藏
页码:161 / 170
页数:10
相关论文
共 99 条
[1]
JAK1 mutations are not frequent events in adult T-ALL: a GRAALL study [J].
Asnafi, Vahid ;
Le Noir, Sandrine ;
Lhermitte, Ludovic ;
Gardin, Claude ;
Legrand, Faezeh ;
Vallantin, Xavier ;
Malfuson, Jean-Valere ;
Ifrah, Norbert ;
Dombret, Herve ;
Macintyre, Elizabeth .
BRITISH JOURNAL OF HAEMATOLOGY, 2010, 148 (01) :179-179
[2]
Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F [J].
Bandaranayake, Rajintha M. ;
Ungureanu, Daniela ;
Shan, Yibing ;
Shaw, David E. ;
Silvennoinen, Olli ;
Hubbard, Stevan R. .
NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2012, 19 (08) :754-759
[3]
Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders [J].
Baxter, EJ ;
Scott, LM ;
Campbell, PJ ;
East, C ;
Fourouclas, N ;
Swanton, S ;
Vassiliou, GS ;
Bench, AJ ;
Boyd, EM ;
Curtin, N ;
Scott, MA ;
Erber, WN ;
Green, AR .
LANCET, 2005, 365 (9464) :1054-1061
[4]
Tyrosine kinase pathways modulate tumor susceptibility to natural killer cells [J].
Bellucci, Roberto ;
Hong-Nam Nguyen ;
Martin, Allison ;
Heinrichs, Stefan ;
Schinzel, Anna C. ;
Hahn, William C. ;
Ritz, Jerome .
JOURNAL OF CLINICAL INVESTIGATION, 2012, 122 (07) :2369-2383
[5]
Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome [J].
Bercovich, Dani ;
Ganmore, Ithamar ;
Scott, Linda M. ;
Wainreb, Gilad ;
Birger, Yehudit ;
Elimelech, Arava ;
Chen, Shochat ;
Cazzaniga, Giovanni ;
Biondi, Andrea ;
Basso, Giuseppe ;
Cario, Gunnar ;
Schrappe, Martin ;
Stanulla, Martin ;
Strehl, Sabine ;
Haas, Oskar A. ;
Mann, Georg ;
Binder, Vera ;
Borkhardt, Arndt ;
Kempski, Helena ;
Trka, Jan ;
Bielorei, Bella ;
Avigad, Smadar ;
Stark, Batia ;
Smith, Owen ;
Dastugue, Nicole ;
Bourquin, Jean-Pierre ;
Ben Tal, Nir ;
Green, Anthony R. ;
Izraeli, Shai .
LANCET, 2008, 372 (9648) :1484-1492
[6]
Inborn errors of human STAT1: allelic heterogeneity governs the diversity of immunological and infectious phenotypes [J].
Boisson-Dupuis, Stephanie ;
Kong, Xiao-Fei ;
Okada, Satoshi ;
Cypowyj, Sophie ;
Puel, Anne ;
Abel, Laurent ;
Casanova, Jean-Laurent .
CURRENT OPINION IN IMMUNOLOGY, 2012, 24 (04) :364-378
[7]
Stat proteins and oncogenesis [J].
Bromberg, J .
JOURNAL OF CLINICAL INVESTIGATION, 2002, 109 (09) :1139-1142
[8]
Inborn Errors of Human JAKs and STATs [J].
Casanova, Jean-Laurent ;
Holland, Steven M. ;
Notarangelo, Luigi D. .
IMMUNITY, 2012, 36 (04) :515-528
[9]
Autosomal Dominant STAT3 Deficiency and Hyper-IgE Syndrome Molecular, Cellular, and Clinical Features From a French National Survey [J].
Chandesris, Marie-Olivia ;
Melki, Isabelle ;
Natividad, Angels ;
Puel, Anne ;
Fieschi, Claire ;
Yun, Ling ;
Thumerelle, Caroline ;
Oksenhendler, Eric ;
Boutboul, David ;
Thomas, Caroline ;
Hoarau, Cyrille ;
Lebranchu, Yvon ;
Stephan, Jean-Louis ;
Cazorla, Celine ;
Aladjidi, Nathalie ;
Micheau, Marguerite ;
Tron, Francois ;
Baruchel, Andre ;
Barlogis, Vincent ;
Palenzuela, Gilles ;
Mathey, Catherine ;
Dominique, Stephane ;
Body, Gerard ;
Munzer, Martine ;
Fouyssac, Fanny ;
Jaussaud, Rolland ;
Bader-Meunier, Brigitte ;
Mahlaoui, Nizar ;
Blanche, Stephane ;
Debre, Marianne ;
Le Bourgeois, Muriel ;
Gandemer, Virginie ;
Lambert, Nathalie ;
Grandin, Virginie ;
Ndaga, Stephanie ;
Jacques, Corinne ;
Harre, Chantal ;
Forveille, Monique ;
Alyanakian, Marie-Alexandra ;
Durandy, Anne ;
Bodemer, Christine ;
Suarez, Felipe ;
Hermine, Olivier ;
Lortholary, Olivier ;
Casanova, Jean-Laurent ;
Fischer, Alain ;
Picard, Capucine .
MEDICINE, 2012, 91 (04) :E1-E19
[10]
Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor [J].
Changelian, PS ;
Flanagan, ME ;
Ball, DJ ;
Kent, CR ;
Magnuson, KS ;
Martin, WH ;
Rizzuti, BJ ;
Sawyer, PS ;
Perry, BD ;
Brissette, WH ;
McCurdy, SP ;
Kudlacz, EM ;
Conklyn, MJ ;
Elliott, EA ;
Koslov, ER ;
Fisher, MB ;
Strelevitz, TJ ;
Yoon, K ;
Whipple, DA ;
Sun, JM ;
Munchhof, MJ ;
Doty, JL ;
Casavant, JM ;
Blumenkopf, TA ;
Hines, M ;
Brown, MF ;
Lillie, BM ;
Subramanyam, C ;
Shang-Poa, C ;
Milici, AJ ;
Beckius, GE ;
Moyer, JD ;
Su, CY ;
Woodworth, TG ;
Gaweco, AS ;
Beals, CR ;
Littman, BH ;
Fisher, DA ;
Smith, JF ;
Zagouras, P ;
Magna, HA ;
Saltarelli, MJ ;
Johnson, KS ;
Nelms, LF ;
Des Etages, SG ;
Hayes, LS ;
Kawabata, TT ;
Finco-Kent, D ;
Baker, DL ;
Larson, M .
SCIENCE, 2003, 302 (5646) :875-878