The 21-year follow-up of the Cardiovascular Risk in Young Finns Study:: risk factor levels, secular trends and east-west difference

被引:172
作者
Juonala, M
Viikari, JSA
Hutri-Kähönen, N
Pietikäinen, M
Jokinen, E
Taittonen, L
Marniemi, J
Rönnemaa, T
Raitakari, OT
机构
[1] Univ Turku, Ctr Appl & Prevent Cardiovasc Med, Turku, Finland
[2] Univ Turku, Dept Med, Turku, Finland
[3] Univ Tampere, Dept Pediat, FIN-33101 Tampere, Finland
[4] Univ Kuopio, Dept Gen Med, FIN-70211 Kuopio, Finland
[5] Univ Helsinki, Dept Pediat, Helsinki, Finland
[6] Vaasa Cent Hosp, Dept Pediat, Vaasa, Finland
[7] Social Insurance Inst, Res & Dev Unit, Turku, Finland
[8] Univ Turku, Dept Clin Physiol, Turku, Finland
[9] Univ Turku, PET Ctr, Turku, Finland
[10] Univ Oulu, Dept Pediat, SF-90100 Oulu, Finland
关键词
cardiovascular; risk factors; secular trend;
D O I
10.1111/j.1365-2796.2004.01308.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objectives. The Cardiovascular Risk in Young Finns Study is an on-going multicentre study of atherosclerosis precursors in Finnish children and young adults. We have collected risk factor data in the 21-year follow-up performed in 2001. The aims of this analysis were to examine the levels, secular trends and east-west difference in risk factors amongst young adults. Design. Population based follow-up study. Subjects. A total of 2283 participants aged 24-39 years in 2001 (63.5% of the original cohort). Main outcome measures. Levels of serum lipids, apolipoproteins, blood pressure and smoking. Results. The mean serum total cholesterol, low density lipoprotein cholesterol, high density lipoprotein (HDL) cholesterol and triglyceride concentrations in 24-39-year-old adults were 5.16, 3.27, 1.29 and 1.34 mmol L-1, respectively. Total cholesterol (5.21 vs. 5.12 mmol L-1, P = 0.046), HDL cholesterol (1.31 vs. 1.28 mmol L-1, P = 0.027), systolic blood pressure (118 vs. 115 mmHg, P < 0.0001) and diastolic blood pressure (72 vs. 70 mmHg, P < 0.0001) were higher in subjects originating from eastern Finland compared with those from western Finland. Significant secular trends between 1986 and 2001 in 24-year-old subjects (n = 783) included an increase in serum triglycerides and body mass index (BMI), a decrease in blood pressure and HDL cholesterol and a modest 5% decrease in total cholesterol levels. Conclusions. During the past 15 years, BMI and triglyceride levels have increased in young adults in Finland. At the same time, the reduction in cholesterol concentration has been slow. Consistent with persistent regional differences in cardiovascular morbidity within Finland, our data demonstrate significant differences in the levels of cardiovascular risk factors between subjects originating from eastern and western Finland.
引用
收藏
页码:457 / 468
页数:12
相关论文
共 32 条
[1]  
AKERBLOM HK, 1984, ANN CLIN RES, V16, P23
[2]  
AKERBLOM HK, 1985, ACTA PAEDIATR SCAND, P49
[3]   INCREASE IN BODY FATNESS AS A MAJOR DETERMINANT OF CHANGES IN SERUM TOTAL CHOLESTEROL AND HIGH-DENSITY LIPOPROTEIN CHOLESTEROL IN YOUNG MEN OVER A 10-YEAR PERIOD [J].
BERNS, MAM ;
DEVRIES, JHM ;
KATAN, MB .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1989, 130 (06) :1109-1122
[4]   CONFERENCE ON THE HEALTH-EFFECTS OF BLOOD-LIPIDS - OPTIMAL DISTRIBUTIONS FOR POPULATIONS - WORKSHOP REPORT - EPIDEMIOLOGICAL SECTION [J].
BLACKBURN, H ;
BERENSON, GS ;
CHRISTAKIS, G ;
CHRISTIAN, JC ;
EPSTEIN, F ;
FEINLEIB, M ;
HAVAS, S ;
HEISS, G ;
HEYDEN, S ;
JACOBS, D ;
JOOSENS, JV ;
KAGAN, A ;
KANNEL, WB ;
MORRISON, JA ;
ROBERTS, NJ ;
TIGER, L ;
WYNDER, EL .
PREVENTIVE MEDICINE, 1979, 8 (06) :612-678
[5]   HDL cholesterol: Trends in two southeastern New England communities, 1981-1993 [J].
Derby, CA ;
Feldman, HA ;
Bausserman, LL ;
Parker, DR ;
Gans, KM ;
Carleton, RA .
ANNALS OF EPIDEMIOLOGY, 1998, 8 (02) :84-91
[6]   Trends in coronary risk factors in the WHO MONICA Project [J].
Evans, A ;
Tolonen, H ;
Hense, HW ;
Ferrario, M ;
Sans, S ;
Kuulasmaa, K .
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2001, 30 :S35-S40
[7]   Serum total cholesterol concentrations and awareness, treatment, and control of hypercholesterolemia among US adults - Findings from the National Health and Nutrition Examination Survey, 1999 to 2000 [J].
Ford, ES ;
Mokdad, AH ;
Giles, WH ;
Mensah, GA .
CIRCULATION, 2003, 107 (17) :2185-2189
[8]   Secular increases in relative weight and adiposity among children over two decades: The Bogalusa Heart Study [J].
Freedman, DS ;
Srinivasan, SR ;
Valdez, RA ;
Williamson, DF ;
Berenson, GS .
PEDIATRICS, 1997, 99 (03) :420-426
[9]  
FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
[10]   Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Final Report [J].
Grundy, SM ;
Becker, D ;
Clark, LT ;
Cooper, RS ;
Denke, MA ;
Howard, WJ ;
Hunninghake, DB ;
Illingworth, R ;
Luepker, RV ;
McBride, P ;
McKenney, JM ;
Pasternak, RC ;
Stone, NJ ;
Van Horn, L ;
Brewer, HB ;
Cleeman, JI ;
Ernst, ND ;
Gordon, D ;
Levy, D ;
Rifkind, B ;
Rossouw, JE ;
Savage, P ;
Haffner, SM ;
Orloff, DG ;
Proschan, MA ;
Schwartz, JS ;
Sempos, CT ;
Shero, ST ;
Murray, EZ ;
Keller, SA ;
Jehle, AJ .
CIRCULATION, 2002, 106 (25) :3143-3421