The multiple function of Grb2 associated binder (Gab) adaptor/scaffolding protein in immune cell signaling

被引：61

作者：

Sàrmay, G ^{[1
]}

Angyal, A ^{[1
]}

Kertész, A ^{[1
]}

Maus, M ^{[1
]}

Medgyesi, D ^{[1
]}

机构：

[1] Eotvos Lorand Univ, Dept Immunol, H-1117 Budapest, Hungary

来源：

IMMUNOLOGY LETTERS | 2006年 / 104卷 / 1-2期

关键词：

adaptor protein; membrane receptors; signaling; tyrosine phosphorylation;

D O I：

10.1016/j.imlet.2005.11.017

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The Grb2 associated binder (Gab) adaptor/scaffolding protein family comprises conserved proteins: mammalian Gab1, Gab2 and Gab3, Drosophila Dos and Caenorhabditis elegans Soc1. Gab adaptors are involved in multiple signaling pathways mediated by receptor- and nonreceptor protein tyrosine kinases (PTKs), and become phosphorylated upon stimulation by growth factors-, cytokines-, IQ Fc- and antigen receptors. Through its phosphorylated tyrosine containing motifs, proline-rich sequences and pleckstrin homologue (PH) domain Gab adaptors may generate an interacting platform for proteins with SH2 and SH3 domains and may transfer these molecules to the plasma membrane, thereby contributing to their activation. This review will concentrate on the function of mammalian Gab proteins in the signal transduction triggered by immune receptors. (C) 2005 Elsevier B.V. All rights reserved.

引用

页码：76 / 82

页数：7

共 50 条

[1] Phosphorylation of Grb2-associated binder 2 on serine 623 by ERK MAPK regulates its association with the phosphatase SHP-2 and decreases STAT5 activation [J].

Arnaud, M ;

Cronin, C ;

Deon, C ;

Loyaux, D ;

Bertoglio, J .

JOURNAL OF IMMUNOLOGY, 2004, 173 (06) :3962-3971

[2] The dynamics of protein kinase B regulation during B cell antigen receptor engagement [J].

Astoul, E ;

Watton, S ;

Cantrell, D .

JOURNAL OF CELL BIOLOGY, 1999, 145 (07) :1511-1520

[3] Requirement of SHP2 binding to Grb2-associated binder-1 for mitogen-activated protein kinase activation in response to lysophosphatidic acid and epidermal growth factor [J].

Cunnick, JM ;

Dorsey, JF ;

Munoz-Antonia, T ;

Mei, L ;

Wu, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (18) :13842-13848

[4] Regulation of the mitogen-activated protein kinase signaling pathway by SHP2 [J].

Cunnick, JM ;

Meng, SS ;

Ren, Y ;

Desponts, C ;

Wang, HG ;

Djeu, JY ;

Wu, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (11) :9498-9504

[5] Phosphoinositide 3-kinase in immunological systems [J].

Fruman, DA ;

Cantley, LC .

SEMINARS IN IMMUNOLOGY, 2002, 14 (01) :7-18

[6]

Gadina M, 2000, J BIOL CHEM, V275, P26959

[7] Essential role for Gab2 in the allergic response [J].

Gu, HH ;

Saito, K ;

Klaman, LD ;

Shen, JQ ;

Fleming, T ;

Wang, YP ;

Pratt, JC ;

Lin, GS ;

Lim, B ;

Kinet, JP ;

Neel, BG .

NATURE, 2001, 412 (6843) :186-190

[8] Critical role for scaffolding adapter Gab2 in FcγR-mediated phagocytosis [J].

Gu, HH ;

Botelho, RJ ;

Yu, M ;

Grinstein, S ;

Neel, BG .

JOURNAL OF CELL BIOLOGY, 2003, 161 (06) :1151-1161

[9] The 'Gab' in signal transduction [J].

Gu, HH ;

Neel, BG .

TRENDS IN CELL BIOLOGY, 2003, 13 (03) :122-130

[10] Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation [J].

Gu, HH ;

Pratt, JC ;

Burakoff, SJ ;

Neel, BG .

MOLECULAR CELL, 1998, 2 (06) :729-740

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