Enantioselective synthesis of β-hydroxy-α-amino acid esters by aldol coupling using a chiral quaternary ammonium salt as catalyst

被引：205

作者：

Horikawa, M ^{[1
]}

Busch-Petersen, J ^{[1
]}

Corey, EJ ^{[1
]}

机构：

[1] Harvard Univ, Dept Chem & Biol Chem, Cambridge, MA 02138 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 20期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

D O I：

10.1016/S0040-4039(99)00636-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A variety of chiral beta-hydroxy-alpha-amino acids and derivatives thereof can be synthesized enantioselectively using the aldol reaction of an aldehyde, the glycinate 1 and the cinchonidine-derived catalyst 2, as indicated in Schemes 1 and 2 and Table 1. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：3843 / 3846

页数：4

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