Stereotactic Radiosurgery and Bevacizumab for Recurrent Glioblastoma Multiforme

被引：20

作者：

Cabrera, Alvin R. ^{[1
]}

Cuneo, Kyle C. ^{[1
]}

Vredenburgh, James J. ^{[2
,3
,4
]}

Sampson, John H. ^{[1
,3
,4
]}

Kirkpatrick, John P. ^{[1
,4
]}

机构：

[1] Duke Univ, Med Ctr, Dept Radiat Oncol, Duke Canc Inst, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Dept Med, Duke Canc Inst, Durham, NC 27710 USA

[3] Duke Univ, Med Ctr, Dept Surg, Duke Canc Inst, Durham, NC 27710 USA

[4] Duke Univ, Med Ctr, Preston Robert Tisch Brain Tumor Ctr, Durham, NC 27710 USA

来源：

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK | 2012年 / 10卷 / 06期

关键词：

PHASE-II TRIAL; RADIATION-THERAPY; PLUS IRINOTECAN; RADIOTHERAPY; SURVIVAL; EFFICACY;

D O I：

10.6004/jnccn.2012.0072

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Despite contemporary surgery, image-guided radiotherapy, and chemotherapy, glioblastoma multiforme (GBM) persists or relapses in nearly all patients, and tumors almost always recur locally. Management of recurrent GBM is variable, but approaches include best supportive care, reoperation, reirradiation, and/or systemic therapy. Promising novel therapies include antiangiogenic agents and stereotactic radiosurgery, which have cytotoxic effects on tumor microvasculature. Emerging data suggest the safety and efficacy of bevacizumab and radiosurgery either alone or in combination. This report presents the case of a man with locally recurrent GBM treated with stereotactic radiosurgery and concurrent bevacizumab, and reviews the preclinical and clinical data supporting this approach. (JNCCN 2012;10:695-699)

引用

页码：695 / 699

页数：5

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