NMDA receptor antagonists sustain LTP and spatial memory: active processes mediate LTP decay

被引:147
作者
Villarreal, DM
Do, V
Haddad, E
Derrick, BE
机构
[1] Univ Texas, Dept Biol, San Antonio, TX 78249 USA
[2] Univ Texas, Cajal Neurosci Res Ctr, Div Life Sci, San Antonio, TX 78249 USA
关键词
D O I
10.1038/nn776
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Although long-term potentiation (LTP) is long-lasting, it is not permanent and decays within weeks after its induction. Little is known about the processes underlying this decay. Here we assessed the contribution of synaptic activity to LTP decay by determining the effect of the competitive NMDA receptor antagonist CPP on the decay of perforant path-dentate LTR CPP blocked decay over a one-week period when administered daily following the induction of LTP, and blocked decay of the late, protein-synthesis-dependent phase of LTP when administered two days after LTP induction. CPP administered for a five-day period following spatial memory training enhanced subsequent memory retention. These data suggest that LTP is normally a persistent process that is actively reversed by NMDA receptor activation, and that both the early and late phases of LTP are dynamic processes regulated by NMDA receptors. These data also support the view that LTP is involved in maintaining spatial memory.
引用
收藏
页码:48 / 52
页数:5
相关论文
共 37 条
[1]   EFFECTS OF THE NMDA RECEPTOR CHANNEL ANTAGONISTS CPP AND MK801 ON HIPPOCAMPAL FIELD POTENTIALS AND LONG-TERM POTENTIATION IN ANESTHETIZED RATS [J].
ABRAHAM, WC ;
MASON, SE .
BRAIN RESEARCH, 1988, 462 (01) :40-46
[2]   ASYMMETRIC RELATIONSHIPS BETWEEN HOMOSYNAPTIC LONG-TERM POTENTIATION AND HETEROSYNAPTIC LONG-TERM DEPRESSION [J].
ABRAHAM, WC ;
GODDARD, GV .
NATURE, 1983, 305 (5936) :717-719
[3]   Toward a molecular definition of long-term memory storage [J].
Bailey, CH ;
Bartsch, D ;
Kandel, ER .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (24) :13445-13452
[4]   AN AGE COMPARISON OF THE RATES OF ACQUISITION AND FORGETTING OF SPATIAL INFORMATION IN RELATION TO LONG-TERM ENHANCEMENT OF HIPPOCAMPAL SYNAPSES [J].
BARNES, CA ;
MCNAUGHTON, BL .
BEHAVIORAL NEUROSCIENCE, 1985, 99 (06) :1040-1048
[5]   MEMORY DEFICITS ASSOCIATED WITH SENESCENCE - NEUROPHYSIOLOGICAL AND BEHAVIORAL-STUDY IN THE RAT [J].
BARNES, CA .
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY, 1979, 93 (01) :74-104
[6]   Effects of the uncompetitive NMDA receptor antagonist memantine on hippocampal long-term potentiation, short-term exploratory modulation and spatial memory in awake, freely moving rats [J].
Barnes, CA ;
Danysz, W ;
Parsons, CG .
EUROPEAN JOURNAL OF NEUROSCIENCE, 1996, 8 (03) :565-571
[7]   Long-term depression in hippocampus [J].
Bear, MF ;
Abraham, WC .
ANNUAL REVIEW OF NEUROSCIENCE, 1996, 19 :437-462
[8]   LONG-LASTING POTENTIATION OF SYNAPTIC TRANSMISSION IN DENTATE AREA OF ANESTHETIZED RABBIT FOLLOWING STIMULATION OF PERFORANT PATH [J].
BLISS, TVP ;
LOMO, T .
JOURNAL OF PHYSIOLOGY-LONDON, 1973, 232 (02) :331-356
[9]   A SYNAPTIC MODEL OF MEMORY - LONG-TERM POTENTIATION IN THE HIPPOCAMPUS [J].
BLISS, TVP ;
COLLINGRIDGE, GL .
NATURE, 1993, 361 (6407) :31-39
[10]   NMDA-DEPENDENT HETEROSYNAPTIC LONG-TERM DEPRESSION IN THE DENTATE GYRUS OF ANESTHETIZED RATS [J].
CHRISTIE, BR ;
ABRAHAM, WC .
SYNAPSE, 1992, 10 (01) :1-6