P53 mutations in lymphomas: position matters

被引:13
作者
Levine, Arnold J. [1 ]
Vosburgh, Evan
机构
[1] Canc Inst New Jersey, New Brunswick, NJ 08903 USA
关键词
D O I
10.1182/blood-2008-07-167718
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The p53 protein integrates the combination of mutations that cause a cancer with the set of environmental stresses that act on that cancer. Mutations in the p53 gene can therefore have dramatic impacts on the overall survival of cancer patients.
引用
收藏
页码:2997 / 2998
页数:2
相关论文
共 7 条
[1]   Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy [J].
Blandino, G ;
Levine, AJ ;
Oren, M .
ONCOGENE, 1999, 18 (02) :477-485
[2]   TP53 MUTATIONS AND BREAST-CANCER PROGNOSIS - PARTICULARLY POOR SURVIVAL RATES FOR CASES WITH MUTATIONS IN THE ZINC-BINDING DOMAINS [J].
BORRESEN, AL ;
ANDERSEN, TI ;
EYFJORD, JE ;
CORNELIS, RS ;
THORLACIUS, S ;
BORG, A ;
JOHANSSON, U ;
THEILLET, C ;
SCHERNECK, S ;
HARTMAN, S ;
CORNELISSE, CJ ;
HOVIG, E ;
DEVILEE, P .
GENES CHROMOSOMES & CANCER, 1995, 14 (01) :71-75
[3]   P53 MUTATIONS IN HUMAN CANCERS [J].
HOLLSTEIN, M ;
SIDRANSKY, D ;
VOGELSTEIN, B ;
HARRIS, CC .
SCIENCE, 1991, 253 (5015) :49-53
[4]   The P53 pathway: what questions remain to be explored? [J].
Levine, A. J. ;
Hu, W. ;
Feng, Z. .
CELL DEATH AND DIFFERENTIATION, 2006, 13 (06) :1027-1036
[5]   What have animal models taught us about the p53 pathway? [J].
Lozano, G ;
Zambetti, GP .
JOURNAL OF PATHOLOGY, 2005, 205 (02) :206-220
[6]   The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer [J].
Olivier, M ;
Langerod, A ;
Carrieri, P ;
Bergh, J ;
Klaar, S ;
Eyfjord, J ;
Theillet, C ;
Rodriguez, C ;
Lidereau, R ;
Bièche, I ;
Varley, J ;
Bignon, Y ;
Uhrhammer, N ;
Winqvist, R ;
Jukkola-Vuorinen, A ;
Niederacher, D ;
Kato, S ;
Ishioka, C ;
Hainaut, P ;
Borresen-Dale, AL .
CLINICAL CANCER RESEARCH, 2006, 12 (04) :1157-1167
[7]   P53 gain-of-function cancer mutants induce genetic instability by inactivating ATM [J].
Song, Hoseok ;
Hollstein, Monica ;
Xu, Yang .
NATURE CELL BIOLOGY, 2007, 9 (05) :573-U166