In vitro and computational studies of transdermal perfusion of nanoformulations containing a large molecular weight protein

被引：25

作者：

Martins, Madalena ^{[1
]}

Azoia, Nuno G. ^{[1
]}

Ribeiro, Artur ^{[1
]}

Shimanovich, Ulyana ^{[2
]}

Silva, Carla ^{[1
]}

Cavaco-Paulo, Artur ^{[1
]}

机构：

[1] Univ Minho, Ctr Biol Engn, IBB, P-4710057 Braga, Portugal

[2] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2013年 / 108卷

关键词：

Protein; Surfactant; Nanodispersion; Transdermal perfusion; Hydrophilic macromolecules; HUMAN STRATUM-CORNEUM; DRUG-DELIVERY; PERCUTANEOUS-ABSORPTION; LIQUID-CHROMATOGRAPHY; ISOPROPYL MYRISTATE; AQUEOUS-SOLUTIONS; HUMAN-SKIN; PIG; PENETRATION; MODEL;

D O I：

10.1016/j.colsurfb.2013.02.032

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 [生物物理学];

摘要：

Transdermal perfusion of a large protein is reported for the first time, using a nanoemulsion of bovine serum albumin (66 kDa) of 160 nm prepared by a solid-in-oil (S/O) process. Molecular dynamics simulations confirmed skin permeation by these formulations, with integration of the protein into the lipid bilayers. These results demonstrate the real possibility of delivering large proteins transdermally for a range of medical and cosmetic applications. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：271 / 278

页数：8

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