Vaccination Against and Treatment of Acute Herpes Zoster for Prevention of Post-Herpetic Neuralgia

被引：13

作者：

Kanbayashi, Yuko ^{[1
,2
,3
]}

Hosokawa, Toyoshi ^{[2
,3
,4
,5
]}

机构：

[1] Kyoto Prefectural Univ Med, Dept Hosp Pharm, Kamigyo Ku, Kyoto 6028566, Japan

[2] Kyoto Prefectural Univ Med, Dept Pain Treatment, Univ Hosp, Kyoto 6028566, Japan

[3] Kyoto Prefectural Univ Med, Palliat Care Unit, Univ Hosp, Kyoto 6028566, Japan

[4] Kyoto Prefectural Univ Med, Dept Anesthesiol, Grad Sch Med Sci, Kyoto 6028566, Japan

[5] Kyoto Prefectural Univ Med, Dept Pain Management & Palliat Care Med, Kyoto 6028566, Japan

来源：

CURRENT PAIN AND HEADACHE REPORTS | 2013年 / 17卷 / 10期

关键词：

Varicella zoster virus; Herpes zoster; Zostavax; Zoster vaccine; Post-herpetic neuralgia; SHINGLES PREVENTION; COST-EFFECTIVENESS; NEUROPATHIC PAIN; MANAGEMENT; SAFETY; RECOMMENDATIONS; STRATEGIES; EFFICACY;

D O I：

10.1007/s11916-013-0371-6

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Zostavax (zoster vaccine) is a 1-dose, high-potency, live, attenuated varicella zoster virus (VZV) vaccine that boosts VZV-specific cell-mediated immunity (CMI), and this is its presumed mechanism of action. Other strategies focus on preventing the major complication of HZ, post-herpetic neuralgia (PHN). Evidence that the vaccine is effective in older patients comes from the pivotal Shingles Prevention Study. That study demonstrated that HZ vaccine significantly reduced morbidity due to HZ and PHN in older patients. However, the duration of efficacy beyond 5 years after vaccination remains unclear. The Long-Term Persistence Substudy, currently under analysis, may provide additional data on the duration of efficacy for zoster vaccine. This review discusses vaccination against HZ, and further reviews recent pharmacotherapy for prevention of PHN.

引用

页数：7

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