From fish to amphibians to mammals: in search of novel strategies to optimize cardiac regeneration

被引：69

作者：

Ausoni, Simonetta ^{[1
]}

Sartore, Saverio ^{[2
]}

机构：

[1] Univ Padua, Dept Biomed Sci, I-35121 Padua, Italy

[2] Univ Padua, Stem Cell Unit, I-35121 Padua, Italy

来源：

JOURNAL OF CELL BIOLOGY | 2009年 / 184卷 / 03期

关键词：

EPICARDIUM-DERIVED CELLS; CARDIOVASCULAR PROGENITOR CELLS; ZEBRAFISH HEART REGENERATION; NEWT LIMB REGENERATION; STEM-CELLS; SMOOTH-MUSCLE; MYOCARDIAL-INFARCTION; MOUSE HEART; ADULT NEWT; CARDIOMYOCYTE;

D O I：

10.1083/jcb.200810094

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Different vertebrate species have different cardiac regeneration rates: high in teleost fish, moderate in urodele amphibians, and almost negligible in mammals. Regeneration may occur through stem and progenitor cell differentiation or via dedifferentiation with residual cardiomyocytes reentering the cell cycle. In this review, we will examine the ability of zebra fish and newts to respond to cardiac damage with de novo cardiogenesis, whereas rodents and humans respond with a marked fibrogenic response and virtually no cardiomyocyte regeneration. Concerted strategies are needed to overcome this evolutionarily imposed barrier and optimize cardiac regeneration in mammals.

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收藏

页码：357 / 364

页数：8

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