Cellular signaling pathways engaged by the Epstein-Barr virus transforming protein LMP1

被引：49

作者：

Hatzivassiliou, E

Mosialos, G

机构：

[1] Biomed Sci Res Ctr Al Fleming, Inst Immunol, Vari 16672, Greece

[2] Aristotelian Univ Thessaloniki, Dept Biol, GR-54006 Thessaloniki, Greece

来源：

FRONTIERS IN BIOSCIENCE | 2002年 / 7卷

关键词：

tumorigenesis; lymphomas; nasopharyngeal carcinoma; latent membrane protein 1; tumor necrosis factor receptor associated factors; NF-kappa B; AP-1; review;

D O I：

10.2741/hatziva

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV) is an essential component of the viral machinery that orchestrates cellular transformation and oncogenesis. The critical role of LMP1 in transformation has been established through recombinant genetic analysis of the EBV genome, ectopic expression in cell lines and transgenic mice and immunohistochemical analysis of EBV-associated tumor specimens. The principal mechanism of LMP1 function is based on mimicry of activated cell surface receptors of the tumor necrosis factor superfamily. LMP1 signaling culminates in the activation of transcription factors NF-kappaB, AP1 and STAT1/3, which have been tightly linked to prevention of apoptosis and malignant transformation. The molecular mechanisms of LMP1 function will be reviewed in this report.

引用

页码：D319 / D329

页数：11

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