A Systematic Review and Meta-Analysis of Ginkgo biloba in Neuropsychiatric Disorders: From Ancient Tradition to Modern-Day Medicine

被引：42

作者：

Brondino, Natascia ^{[1
]}

De Silvestri, Annalisa ^{[2
]}

Re, Simona ^{[1
]}

Lanati, Niccolo ^{[3
]}

Thiemann, Pia ^{[4
]}

Verna, Anna ^{[1
]}

Emanuele, Enzo ^{[1
]}

Politi, Pierluigi ^{[1
]}

机构：

[1] Univ Pavia, Sect Psychiat, Dept Brain & Behav Sci, I-27100 Pavia, Italy

[2] Fdn IRCCS Policlin San Matteo, Biometr & Stat Unit, I-27100 Pavia, Italy

[3] Univ Pavia, Sect Psychiat, Dept Publ Hlth Neurosci Expt & Forens Med, I-27100 Pavia, Italy

[4] Ruhr Univ Bochum, Inst Psychol, D-44801 Bochum, Germany

来源：

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2013年 / 2013卷

关键词：

EXTRACT EGB 761; PLACEBO-CONTROLLED TRIAL; DOUBLE-BLIND; ALZHEIMERS-DISEASE; RATING-SCALE; IN-VITRO; DEMENTIA; EFFICACY; DONEPEZIL; FEATURES;

D O I：

10.1155/2013/915691

中图分类号：

R [医药、卫生];

学科分类号：

100218 [急诊医学];

摘要：

Ginkgo biloba (Gb) has demonstrated antioxidant and vasoactive properties as well as clinical benefits in several conditions such as ischemia, epilepsy, and peripheral nerve damage. Additionally, Gb is supposed to act as potential cognitive enhancer in dementia. So far, several trials have been conducted to investigate the potential effectiveness of Gb in neuropsychiatric conditions. However, the results of these studies remain controversial. We conducted a systematic review and a meta-analysis of three randomised controlled trials in patients with schizophrenia and eight randomised controlled trials in patients with dementia. Gb treatment reduced positive symptoms in patients with schizophrenia and improved cognitive function and activities of daily living in patients with dementia. No effect of Gb on negative symptoms in schizophrenic patients was found. The general lack of evidence prevents drawing conclusions regarding Gb effectiveness in other neuropsychiatric conditions (i.e., autism, depression, anxiety, attention-deficit hyperactivity disorder, and addiction). Our data support the use of Gb in patients with dementia and as an adjunctive therapy in schizophrenic patients.

引用

页数：11

共 53 条

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